Alendronate sodium and Joint contracture - a phase IV clinical study of FDA data

Summary:

Joint contracture is reported as a side effect among people who take Alendronate sodium (alendronate sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Fosamax, and have Pain.

The phase IV clinical study analyzes which people have Joint contracture when taking Alendronate sodium. It is created by eHealthMe based on reports of 42,896 people who have side effects when taking Alendronate sodium from the FDA, and is updated regularly.

What is Alendronate sodium?

Alendronate sodium has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 43,608 Alendronate sodium users. Check the latest studies of Alendronate sodium.

What is Joint contracture?

Joint contracture (a permanent shortening of a muscle or joint) is found to be associated with 333 drugs and 653 conditions by eHealthMe. Check the latest studies of Joint contracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

42,896 people reported to have side effects when taking Alendronate sodium.
Among them, 49 people (0.11%) have Joint contracture.

Could Alendronate sodium cause Joint contracture?

Among these 49 people:

How long have people been on Alendronate sodium when they have Joint contracture? *

What is the gender of people who have Joint contracture when taking Alendronate sodium? *

female: 93.88 %
male: 6.12 %

What is the age of people who have Joint contracture when taking Alendronate sodium? *

What are other drugs people take besides Alendronate sodium? *

What are other side effects people have besides Joint contracture? *

Femur Fracture: 33 people, 67.35%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 28 people, 57.14%
Pain: 22 people, 44.90%
Pain In Extremity: 21 people, 42.86%
Muscle Spasms (muscle contraction): 20 people, 40.82%
Urinary Tract Infection: 19 people, 38.78%
Fall: 17 people, 34.69%
Fracture Nonunion (permanent failure of healing following a broken bone): 17 people, 34.69%
Anaemia (lack of blood): 16 people, 32.65%
Dehydration (dryness resulting from the removal of water): 16 people, 32.65%

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 12.24%
Pain: 6 people, 12.24%
Type 1 Diabetes: 5 people, 10.20%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.16%
Anaemia (lack of blood): 3 people, 6.12%
Stress And Anxiety: 3 people, 6.12%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.12%
Nuclear Magnetic Resonance Imaging Abdominal: 3 people, 6.12%
Osteomalacia (softening of the bones due to a lack of vitamin d): 2 people, 4.08%
Chest Pain: 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Alendronate sodium and have Joint contracture?

- Check whether Joint contracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Alendronate sodium:

Alendronate sodium (43,608 reports)

Browse all side effects of Alendronate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint contracture:

Joint contracture (333 drugs)

Browse all the conditions that are associated with Joint contracture:

Joint contracture (653 conditions)

Related publications that referenced our studies

Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .
Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium (the active ingredients of Alendronate sodium) and Alendronate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.