Alendronic acid and Lymphoedema - a phase IV clinical study of FDA data

Summary:

Lymphoedema is reported as a side effect among people who take Alendronic acid (alendronate sodium), especially for people who are female, 50-59 old, also take Atrovent Hfa, and have Oesophageal pain.

The phase IV clinical study analyzes which people have Lymphoedema when taking Alendronic acid. It is created by eHealthMe based on reports of 18,142 people who have side effects when taking Alendronic acid from the FDA, and is updated regularly.

What is Alendronic acid?

Alendronic acid has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 18,408 Alendronic acid users. Check the latest studies of Alendronic acid.

What is Lymphoedema?

Lymphoedema (localized fluid retention and tissue swelling) is found to be associated with 912 drugs and 743 conditions by eHealthMe. Check the latest studies of Lymphoedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

18,142 people reported to have side effects when taking Alendronic acid.
Among them, 17 people (0.09%) have Lymphoedema.

Could Alendronic acid cause Lymphoedema?

Among these 17 people:

What is the gender of people who have Lymphoedema when taking Alendronic acid? *

female: 100 %
male: 0.0 %

What is the age of people who have Lymphoedema when taking Alendronic acid? *

What are other drugs people take besides Alendronic acid? *

What are other side effects people have besides Lymphoedema? *

Dizziness: 16 people, 94.12%
Malaise (a feeling of general discomfort or uneasiness): 16 people, 94.12%
Fatigue (feeling of tiredness): 16 people, 94.12%
Nausea And Vomiting: 16 people, 94.12%
Urinary Tract Infection: 16 people, 94.12%
Rashes (redness): 16 people, 94.12%
Hallucinations (sensations that appear real but are created by your mind): 16 people, 94.12%
Fibromyalgia (a long-term condition which causes pain all over the body): 16 people, 94.12%
Diarrhea: 16 people, 94.12%
Pneumonia: 16 people, 94.12%

What are the existing conditions these people have? *

Malaise (a feeling of general discomfort or uneasiness): 15 people, 88.24%
Oesophageal Spasm (contraction of oesophagus): 15 people, 88.24%
Depression: 15 people, 88.24%
Fluid Retention (an abnormal accumulation of fluid in the blood): 15 people, 88.24%
Hallucinations (sensations that appear real but are created by your mind): 15 people, 88.24%
Iron Deficiency: 15 people, 88.24%
Itching: 15 people, 88.24%
Urticaria (rash of round, red welts on the skin that itch intensely): 15 people, 88.24%
Nausea And Vomiting: 15 people, 88.24%
Oesophageal Pain: 15 people, 88.24%

* Approximation only. Some reports may have incomplete information.

Do you take Alendronic acid and have Lymphoedema?

- Check whether Lymphoedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Alendronic acid:

Alendronic acid (18,408 reports)

Lymphoedema treatments and more:

Lymphoedema (9,453 reports)

Browse all side effects of Alendronic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphoedema:

Lymphoedema (912 drugs)

Browse all the conditions that are associated with Lymphoedema:

Lymphoedema (743 conditions)

Related publications that referenced our studies

Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .
Stuckey BG, Sallie R, "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", Osteoporosis International, 2015 Jan .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium (the active ingredients of Alendronic acid) and Alendronic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.