Aleve pm and Itching - a phase IV clinical study of FDA data

Summary:

Itching is reported as a side effect among people who take Aleve pm (diphenhydramine hydrochloride; naproxen sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aleve, and have Pain.

The phase IV clinical study analyzes which people have Itching when taking Aleve pm. It is created by eHealthMe based on reports of 2,081 people who have side effects when taking Aleve pm from the FDA, and is updated regularly.

What is Aleve pm?

Aleve pm has active ingredients of diphenhydramine hydrochloride; naproxen sodium. eHealthMe is studying from 2,094 Aleve pm users. Check the latest studies of Aleve pm.

What is Itching?

Itching is found to be associated with 3,211 drugs and 4,535 conditions by eHealthMe. Check the latest studies of Itching.

On Jul, 20, 2026

2,081 people reported to have side effects when taking Aleve pm.
Among them, 33 people (1.59%) have Itching.

Among these 33 people:

How long have people been on Aleve pm when they have Itching? *

What is the gender of people who have Itching when taking Aleve pm? *

female: 56.67 %
male: 43.33 %

What is the age of people who have Itching when taking Aleve pm? *

What are other drugs people take besides Aleve pm? *

What are other side effects people have besides Itching? *

Rashes (redness): 13 people, 39.39%
Peripheral Swelling: 10 people, 30.30%
Fatigue (feeling of tiredness): 5 people, 15.15%
Angioedema (rapid swelling of the dermis): 4 people, 12.12%
Drug Hypersensitivity: 4 people, 12.12%
Dyspnea (difficult or laboured breathing): 4 people, 12.12%
Fall: 4 people, 12.12%
Joint Swelling: 4 people, 12.12%
Melanocytic Naevus (a type of lesion that contains nevus cells (a type of melanocyte)): 4 people, 12.12%
Insomnia (sleeplessness): 4 people, 12.12%

What are the existing conditions these people have? *

Pain: 10 people, 30.30%
Back Pain: 6 people, 18.18%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 12.12%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 3 people, 9.09%
Headache (pain in head): 3 people, 9.09%
Insomnia (sleeplessness): 2 people, 6.06%
Hot Flush (sudden feelings of heat): 2 people, 6.06%
Bone Pain: 2 people, 6.06%
Swallowing Difficulty: 1 person, 3.03%
Sleep Disorder: 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve pm and have Itching?

- Check whether Itching is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve pm:

Aleve pm (2,094 reports)

Itching treatments and more:

Itching (398,821 reports)

How severe was Itching and when was it recovered:

Itching in Aleve pm

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride; naproxen sodium:

Itching and drugs with ingredients of diphenhydramine hydrochloride; naproxen sodium (33 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aleve pm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Itching:

Itching (3,211 drugs)

Browse all the conditions that are associated with Itching:

Itching (4,535 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride; naproxen sodium (the active ingredients of Aleve pm) and Aleve pm (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.