Aleve and Infusion site bruising - a phase IV clinical study of FDA data

Summary:

Infusion site bruising is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 60+ old, also take Epinephrine, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Infusion site bruising when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Infusion site bruising?

Infusion site bruising is found to be associated with 413 drugs and 183 conditions by eHealthMe. Check the latest studies of Infusion site bruising.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 22 people (0.03%) have Infusion site bruising.

Could Aleve cause Infusion site bruising?

Among these 22 people:

What is the gender of people who have Infusion site bruising when taking Aleve? *

female: 100 %
male: 0.0 %

What is the age of people who have Infusion site bruising when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Infusion site bruising? *

Malaise (a feeling of general discomfort or uneasiness): 13 people, 59.09%
Fall: 13 people, 59.09%
Fatigue (feeling of tiredness): 13 people, 59.09%
Weight Decreased: 12 people, 54.55%
Dizziness: 12 people, 54.55%
Infusion Site Haemorrhage (bleeding from infusion site): 11 people, 50.00%
Infusion Site Pain: 9 people, 40.91%
Weight Increased: 9 people, 40.91%
Urinary Tract Infection: 8 people, 36.36%
Multiple Allergies (allergy to multiple agents): 8 people, 36.36%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 19 people, 86.36%
Primary Immunodeficiency Syndrome: 8 people, 36.36%
Urinary Tract Infection: 4 people, 18.18%
Immune System Disorder: 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 9.09%
Dyspnea (difficult or laboured breathing): 1 person, 4.55%
Cough: 1 person, 4.55%
Asthma: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Infusion site bruising?

- Check whether Infusion site bruising is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Infusion site bruising:

Infusion site bruising (413 drugs)

Browse all the conditions that are associated with Infusion site bruising:

Infusion site bruising (183 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.