Aleve and Joint lock - a phase IV clinical study of FDA data

Summary:

Joint lock is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 60+ old, also take Vitamin D, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint lock when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Joint lock?

Joint lock is found to be associated with 302 drugs and 490 conditions by eHealthMe. Check the latest studies of Joint lock.

On Jul, 05, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 16 people (0.02%) have Joint lock.

Among these 16 people:

What is the gender of people who have Joint lock when taking Aleve? *

female: 60 %
male: 40 %

What is the age of people who have Joint lock when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Joint lock? *

Pain In Extremity: 4 people, 25.00%
Joint Pain: 3 people, 18.75%
Chills (felling of cold): 3 people, 18.75%
Drug Ineffective: 3 people, 18.75%
Fall: 3 people, 18.75%
Monoplegia (a paralysis of a single limb): 3 people, 18.75%
Muscle Aches (muscle pain): 3 people, 18.75%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 18.75%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2 people, 12.50%
Tendonitis (a condition that causes pain and swelling of tendons): 2 people, 12.50%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 18.75%
Sleep Disorder: 2 people, 12.50%
Interstitial Lung Disease: 2 people, 12.50%
Cough: 2 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%
Bladder Disorder: 1 person, 6.25%
Bone Density Abnormal: 1 person, 6.25%
Breast Cancer Stage I: 1 person, 6.25%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Joint lock?

- Check whether Joint lock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Joint lock treatments and more:

Joint lock (3,416 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint lock:

Joint lock (302 drugs)

Browse all the conditions that are associated with Joint lock:

Joint lock (490 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.