Aleve and Left ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Left ventricular dysfunction is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are male, 60+ old, also take Coumadin, and have Non-hodgkin's lymphoma.

The phase IV clinical study analyzes which people have Left ventricular dysfunction when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Left ventricular dysfunction?

Left ventricular dysfunction is found to be associated with 894 drugs and 792 conditions by eHealthMe. Check the latest studies of Left ventricular dysfunction.

On May, 24, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 20 people (0.03%) have Left ventricular dysfunction.

Could Aleve cause Left ventricular dysfunction?

Among these 20 people:

What is the gender of people who have Left ventricular dysfunction when taking Aleve? *

female: 35 %
male: 65 %

What is the age of people who have Left ventricular dysfunction when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Left ventricular dysfunction? *

Cardiac Failure Congestive: 8 people, 40.00%
Weakness: 7 people, 35.00%
Stress And Anxiety: 7 people, 35.00%
Fever: 7 people, 35.00%
Fatigue (feeling of tiredness): 7 people, 35.00%
Cellulitis (infection under the skin): 7 people, 35.00%
Cardiomyopathy (weakening of the heart muscle): 7 people, 35.00%
Pericardial Effusion (fluid around the heart): 7 people, 35.00%
Atelectasis (partial or complete collapse of the lung): 7 people, 35.00%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 7 people, 35.00%

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 20.00%
Osteoporosis (bones weak and more likely to break): 3 people, 15.00%
Anaplastic Thyroid Cancer (thyroid cancer which has a very poor prognosis): 3 people, 15.00%
Bone Loss: 3 people, 15.00%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 10.00%
Heart Rate Irregular: 2 people, 10.00%
Type 2 Diabetes: 1 person, 5.00%
Chest Pain: 1 person, 5.00%
Aplastic Anemia: 1 person, 5.00%
Arrhythmias (irregular heartbeat): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Left ventricular dysfunction?

- Check whether Left ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (894 drugs)

Browse all the conditions that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (792 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.