Aleve and Unilateral hydronephrosis - a phase IV clinical study of FDA data

Summary:

Unilateral hydronephrosis is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are male, 60+ old, also take Tylenol, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Unilateral hydronephrosis when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Unilateral hydronephrosis?

Unilateral hydronephrosis (kidney stone that causes obstruction of the ureter) is found to be associated with 1,010 drugs and 1,194 conditions by eHealthMe. Check the latest studies of Unilateral hydronephrosis.

On Jul, 15, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 32 people (0.05%) have Unilateral hydronephrosis.

Could Aleve cause Unilateral hydronephrosis?

Among these 32 people:

What is the gender of people who have Unilateral hydronephrosis when taking Aleve? *

female: 50 %
male: 50 %

What is the age of people who have Unilateral hydronephrosis when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Unilateral hydronephrosis? *

Fatigue (feeling of tiredness): 11 people, 34.38%
Chest Pain: 11 people, 34.38%
Anaemia (lack of blood): 11 people, 34.38%
Pleural Effusion (water on the lungs): 11 people, 34.38%
Dyspnea (difficult or laboured breathing): 11 people, 34.38%
Fall: 10 people, 31.25%
Respiratory Disorder (respiratory disease): 10 people, 31.25%
Joint Pain: 10 people, 31.25%
Nausea (feeling of having an urge to vomit): 10 people, 31.25%
Back Pain: 10 people, 31.25%

What are the existing conditions these people have? *

Stress And Anxiety: 11 people, 34.38%
Constipation: 8 people, 25.00%
Metastases To Bone (cancer spreads to bone): 7 people, 21.88%
Panic Disorder: 6 people, 18.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 15.62%
Breast Cancer: 5 people, 15.62%
Muscle Spasms (muscle contraction): 4 people, 12.50%
Joint Pain: 4 people, 12.50%
Birth Control: 3 people, 9.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Unilateral hydronephrosis?

- Check whether Unilateral hydronephrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Unilateral hydronephrosis:

Unilateral hydronephrosis (1,010 drugs)

Browse all the conditions that are associated with Unilateral hydronephrosis:

Unilateral hydronephrosis (1,194 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.