Allopurinol and Breakthrough pain - a phase IV clinical study of FDA data

Summary:

Breakthrough pain is reported as a side effect among people who take Allopurinol (allopurinol), especially for people who are male, 60+ old, also take Lorazepam, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Breakthrough pain when taking Allopurinol. It is created by eHealthMe based on reports of 188,106 people who have side effects when taking Allopurinol from the FDA, and is updated regularly.

What is Allopurinol?

Allopurinol has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,868 Allopurinol users. Check the latest studies of Allopurinol.

What is Breakthrough pain?

Breakthrough pain is found to be associated with 271 drugs and 417 conditions by eHealthMe. Check the latest studies of Breakthrough pain.

On Aug, 07, 2026

188,106 people reported to have side effects when taking Allopurinol.
Among them, 21 people (0.01%) have Breakthrough pain.

Could Allopurinol cause Breakthrough pain?

Among these 21 people:

What is the gender of people who have Breakthrough pain when taking Allopurinol? *

female: 20 %
male: 80 %

What is the age of people who have Breakthrough pain when taking Allopurinol? *

What are other drugs people take besides Allopurinol? *

Lorazepam: 15 people, 71.43%
Claritin: 14 people, 66.67%
Pamidronate Disodium: 14 people, 66.67%
Coumadin: 14 people, 66.67%
Heparin: 14 people, 66.67%
Prevacid: 14 people, 66.67%
Prilosec: 14 people, 66.67%
Prochlorperazine Maleate: 14 people, 66.67%
Decadron: 14 people, 66.67%
Reglan: 14 people, 66.67%

What are other side effects people have besides Breakthrough pain? *

Weight Decreased: 17 people, 80.95%
High Blood Pressure: 17 people, 80.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 76.19%
Stress And Anxiety: 16 people, 76.19%
Tooth Disorder (tooth disease): 16 people, 76.19%
Urinary Tract Infection: 16 people, 76.19%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 15 people, 71.43%
Constipation: 15 people, 71.43%
Impaired Healing: 15 people, 71.43%
Pain: 15 people, 71.43%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 66.67%
Osteoporosis (bones weak and more likely to break): 2 people, 9.52%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 9.52%
Ventricular Extrasystoles (premature cardiac contraction): 1 person, 4.76%
Nausea (feeling of having an urge to vomit): 1 person, 4.76%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.76%
Back Pain: 1 person, 4.76%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 1 person, 4.76%
Cardiac Failure Chronic: 1 person, 4.76%
Fatigue (feeling of tiredness): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Allopurinol and have Breakthrough pain?

- Check whether Breakthrough pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Allopurinol:

Allopurinol (190,868 reports)

Browse all side effects of Allopurinol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Breakthrough pain:

Breakthrough pain (271 drugs)

Browse all the conditions that are associated with Breakthrough pain:

Breakthrough pain (417 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Allopurinol) and Allopurinol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.