Allopurinol and Diffuse alveolar damage - a phase IV clinical study of FDA data

Summary:

Diffuse alveolar damage is reported as a side effect among people who take Allopurinol (allopurinol), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Voriconazole, and have Acute lymphocytic leukemia (all).

The phase IV clinical study analyzes which people have Diffuse alveolar damage when taking Allopurinol. It is created by eHealthMe based on reports of 188,106 people who have side effects when taking Allopurinol from the FDA, and is updated regularly.

What is Allopurinol?

Allopurinol has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,868 Allopurinol users. Check the latest studies of Allopurinol.

What is Diffuse alveolar damage?

Diffuse alveolar damage (common manifestation of drug-induced lung injury) is found to be associated with 143 drugs and 362 conditions by eHealthMe. Check the latest studies of Diffuse alveolar damage.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

188,106 people reported to have side effects when taking Allopurinol.
Among them, 19 people (0.01%) have Diffuse alveolar damage.

Could Allopurinol cause Diffuse alveolar damage?

Among these 19 people:

How long have people been on Allopurinol when they have Diffuse alveolar damage? *

What is the gender of people who have Diffuse alveolar damage when taking Allopurinol? *

female: 11.11 %
male: 88.89 %

What is the age of people who have Diffuse alveolar damage when taking Allopurinol? *

What are other drugs people take besides Allopurinol? *

What are other side effects people have besides Diffuse alveolar damage? *

Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 10 people, 52.63%
Diarrhea: 7 people, 36.84%
Respiratory Distress (difficulty in breathing): 6 people, 31.58%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 6 people, 31.58%
Alanine Aminotransferase Increased: 6 people, 31.58%
Gallstones (stone formation by bile component): 6 people, 31.58%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 6 people, 31.58%
Pulmonary Oedema (fluid accumulation in the lungs): 6 people, 31.58%
Staphylococcal Infection (an infection with staphylococcus bacteria): 6 people, 31.58%
Pneumonia: 6 people, 31.58%

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 26.32%
Sinusitis (inflammation of sinus): 3 people, 15.79%
Flank Pain (a distressing sensation experienced around the lower back and the upper abdomen): 3 people, 15.79%
High Blood Pressure: 2 people, 10.53%
Nausea (feeling of having an urge to vomit): 2 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 2 people, 10.53%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 10.53%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.26%
Calcium Deficiency (lack of calcium): 1 person, 5.26%
Carotid Artery Stenosis (narrowing of carotid artery): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Allopurinol and have Diffuse alveolar damage?

- Check whether Diffuse alveolar damage is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Allopurinol:

Allopurinol (190,868 reports)

Browse all side effects of Allopurinol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diffuse alveolar damage:

Diffuse alveolar damage (143 drugs)

Browse all the conditions that are associated with Diffuse alveolar damage:

Diffuse alveolar damage (362 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Allopurinol) and Allopurinol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.