Allopurinol and Tonic convulsion - a phase IV clinical study of FDA data

Summary:

Tonic convulsion is reported as a side effect among people who take Allopurinol (allopurinol), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Paracetamol, and have Nausea and vomiting.

The phase IV clinical study analyzes which people have Tonic convulsion when taking Allopurinol. It is created by eHealthMe based on reports of 188,106 people who have side effects when taking Allopurinol from the FDA, and is updated regularly.

What is Allopurinol?

Allopurinol has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,868 Allopurinol users. Check the latest studies of Allopurinol.

What is Tonic convulsion?

Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it) is found to be associated with 160 drugs and 384 conditions by eHealthMe. Check the latest studies of Tonic convulsion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

188,106 people reported to have side effects when taking Allopurinol.
Among them, 14 people (0.01%) have Tonic convulsion.

Could Allopurinol cause Tonic convulsion?

Among these 14 people:

How long have people been on Allopurinol when they have Tonic convulsion? *

What is the gender of people who have Tonic convulsion when taking Allopurinol? *

female: 42.86 %
male: 57.14 %

What is the age of people who have Tonic convulsion when taking Allopurinol? *

What are other drugs people take besides Allopurinol? *

What are other side effects people have besides Tonic convulsion? *

Ventricular Fibrillation (abnormally irregular heart rhythm): 5 people, 35.71%
Dizziness: 5 people, 35.71%
Loss Of Consciousness: 3 people, 21.43%
Skin Discoloration - Bluish (bluish colour of skin): 2 people, 14.29%
Agitation (state of anxiety or nervous excitement): 2 people, 14.29%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 14.29%
Depressed Level Of Consciousness: 2 people, 14.29%
Rashes (redness): 2 people, 14.29%
Hepatic Function Abnormal: 2 people, 14.29%
Nausea (feeling of having an urge to vomit): 2 people, 14.29%

What are the existing conditions these people have? *

Nausea And Vomiting: 5 people, 35.71%
Pneumonia: 1 person, 7.14%
Nephrogenic Anaemia (anaemia due to kidney disease): 1 person, 7.14%
Nausea (feeling of having an urge to vomit): 1 person, 7.14%
Lung Disorder (lung disease): 1 person, 7.14%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 7.14%
Gouty Tophus (a deposit of urates in the skin and tissue around a joint or in the external ear): 1 person, 7.14%
Cellulitis (infection under the skin): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Allopurinol and have Tonic convulsion?

- Check whether Tonic convulsion is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Allopurinol:

Allopurinol (190,868 reports)

Browse all side effects of Allopurinol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tonic convulsion:

Tonic convulsion (160 drugs)

Browse all the conditions that are associated with Tonic convulsion:

Tonic convulsion (384 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Allopurinol) and Allopurinol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.