Alphagan and Peripheral swelling - a phase IV clinical study of FDA data

Summary:

Peripheral swelling is reported as a side effect among people who take Alphagan (brimonidine tartrate), especially for people who are female, 60+ old, also take Lumigan, and have High blood pressure.

The phase IV clinical study analyzes which people have Peripheral swelling when taking Alphagan. It is created by eHealthMe based on reports of 9,802 people who have side effects when taking Alphagan from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Peripheral swelling?

Peripheral swelling is found to be associated with 2,183 drugs and 1,743 conditions by eHealthMe. Check the latest studies of Peripheral swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

9,802 people reported to have side effects when taking Alphagan.
Among them, 79 people (0.81%) have Peripheral swelling.

Could Alphagan cause Peripheral swelling?

Among these 79 people:

What is the gender of people who have Peripheral swelling when taking Alphagan? *

female: 70.42 %
male: 29.58 %

What is the age of people who have Peripheral swelling when taking Alphagan? *

What are other drugs people take besides Alphagan? *

What are other side effects people have besides Peripheral swelling? *

Diarrhea: 14 people, 17.72%
Fatigue (feeling of tiredness): 13 people, 16.46%
Joint Swelling: 12 people, 15.19%
High Blood Pressure: 11 people, 13.92%
Pain In Extremity: 11 people, 13.92%
Back Pain: 10 people, 12.66%
Malaise (a feeling of general discomfort or uneasiness): 10 people, 12.66%
Joint Pain: 9 people, 11.39%
Pneumonia: 8 people, 10.13%
Weakness: 8 people, 10.13%

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 16.46%
Multiple Myeloma (cancer of the plasma cells): 10 people, 12.66%
Pain: 8 people, 10.13%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 6 people, 7.59%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 6.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 5.06%
Type 2 Diabetes: 4 people, 5.06%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.06%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 3.80%
Constipation: 3 people, 3.80%

* Approximation only. Some reports may have incomplete information.

Do you take Alphagan and have Peripheral swelling?

- Check whether Peripheral swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Alphagan:

Alphagan (9,981 reports)

Browse all side effects of Alphagan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral swelling:

Peripheral swelling (2,183 drugs)

Browse all the conditions that are associated with Peripheral swelling:

Peripheral swelling (1,743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate (the active ingredients of Alphagan) and Alphagan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.