Amaryl and Cytolytic hepatitis - a phase IV clinical study of FDA data

Summary:

Cytolytic hepatitis is reported as a side effect among people who take Amaryl (glimepiride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Allopurinol, and have High blood pressure.

The phase IV clinical study analyzes which people have Cytolytic hepatitis when taking Amaryl. It is created by eHealthMe based on reports of 31,980 people who have side effects when taking Amaryl from the FDA, and is updated regularly.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

What is Cytolytic hepatitis?

Cytolytic hepatitis (dissolution or destruction of a liver cell) is found to be associated with 454 drugs and 910 conditions by eHealthMe. Check the latest studies of Cytolytic hepatitis.

On Jul, 23, 2026

31,980 people reported to have side effects when taking Amaryl.
Among them, 28 people (0.09%) have Cytolytic hepatitis.

Among these 28 people:

How long have people been on Amaryl when they have Cytolytic hepatitis? *

What is the gender of people who have Cytolytic hepatitis when taking Amaryl? *

female: 60 %
male: 40 %

What is the age of people who have Cytolytic hepatitis when taking Amaryl? *

What are other drugs people take besides Amaryl? *

Glucophage: 8 people, 28.57%
Allopurinol: 8 people, 28.57%
Lasix: 6 people, 21.43%
Plavix: 4 people, 14.29%
Aspirin: 4 people, 14.29%
Diovan: 3 people, 10.71%
Acetylcysteine: 3 people, 10.71%
Isosorbide Mononitrate: 3 people, 10.71%
Tenormin: 3 people, 10.71%
Lipidil: 3 people, 10.71%

What are other side effects people have besides Cytolytic hepatitis? *

Hepatitis Cholestatic (flow of bile from the liver is slowed or blocked): 7 people, 25.00%
Fever: 6 people, 21.43%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 6 people, 21.43%
Acute Kidney Failure: 5 people, 17.86%
Cardiac Failure: 4 people, 14.29%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 4 people, 14.29%
Nausea (feeling of having an urge to vomit): 4 people, 14.29%
Liver Disorder (liver diseases): 3 people, 10.71%
Rash Morbilliform (a rash that looks like measles): 3 people, 10.71%
Cardiac Failure Congestive: 3 people, 10.71%

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 21.43%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 3 people, 10.71%
Stable Angina (a constant chest pain): 3 people, 10.71%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 3 people, 10.71%
Salivary Gland Calculus (stone in salivary gland): 3 people, 10.71%
Pain: 3 people, 10.71%
Nausea And Vomiting: 3 people, 10.71%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 10.71%
Fever: 2 people, 7.14%
Gout (uric acid crystals building up in the body): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Amaryl and have Cytolytic hepatitis?

- Check whether Cytolytic hepatitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amaryl:

Amaryl (32,259 reports)

Browse all side effects of Amaryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cytolytic hepatitis:

Cytolytic hepatitis (454 drugs)

Browse all the conditions that are associated with Cytolytic hepatitis:

Cytolytic hepatitis (910 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on glimepiride (the active ingredients of Amaryl) and Amaryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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