Amaryl and Hyperammonaemia - a phase IV clinical study of FDA data

Summary:

Hyperammonaemia is reported as a side effect among people who take Amaryl (glimepiride), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Actos, and have Hepatocellular carcinoma.

The phase IV clinical study analyzes which people have Hyperammonaemia when taking Amaryl. It is created by eHealthMe based on reports of 31,980 people who have side effects when taking Amaryl from the FDA, and is updated regularly.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

What is Hyperammonaemia?

Hyperammonaemia is found to be associated with 401 drugs and 560 conditions by eHealthMe. Check the latest studies of Hyperammonaemia.

On Jul, 21, 2026

31,980 people reported to have side effects when taking Amaryl.
Among them, 12 people (0.04%) have Hyperammonaemia.

Among these 12 people:

How long have people been on Amaryl when they have Hyperammonaemia? *

What is the gender of people who have Hyperammonaemia when taking Amaryl? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Hyperammonaemia when taking Amaryl? *

What are other drugs people take besides Amaryl? *

What are other side effects people have besides Hyperammonaemia? *

Depressed Level Of Consciousness: 4 people, 33.33%
Nausea And Vomiting: 4 people, 33.33%
Metastases To Liver (cancer spreads to liver): 3 people, 25.00%
Blood Glucose Increased: 3 people, 25.00%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 3 people, 25.00%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 25.00%
Confusion: 3 people, 25.00%
Cholestatic Liver Injury (due to injury bile cannot floe from liver): 2 people, 16.67%
Electroencephalogram Abnormal: 2 people, 16.67%
Cerebrovascular Disorder (disease of brain): 2 people, 16.67%

What are the existing conditions these people have? *

Hepatocellular Carcinoma (liver cancer): 3 people, 25.00%
Hepatic Neoplasm Malignant (liver cancer): 2 people, 16.67%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 16.67%
Ascites (accumulation of fluid in the abdominal cavity): 2 people, 16.67%
Oropharyngeal Pain: 1 person, 8.33%
Insomnia (sleeplessness): 1 person, 8.33%
Hepatic Function Abnormal: 1 person, 8.33%
Hepatic Failure (liver failure): 1 person, 8.33%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 1 person, 8.33%
Gastritis (inflammation of stomach): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Amaryl and have Hyperammonaemia?

- Check whether Hyperammonaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amaryl:

Amaryl (32,259 reports)

Hyperammonaemia treatments and more:

Hyperammonaemia (6,053 reports)

Browse all side effects of Amaryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperammonaemia:

Hyperammonaemia (401 drugs)

Browse all the conditions that are associated with Hyperammonaemia:

Hyperammonaemia (560 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on glimepiride (the active ingredients of Amaryl) and Amaryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.