Ambien and Angle closure glaucoma - a phase IV clinical study of FDA data

Summary:

Angle closure glaucoma is reported as a side effect among people who take Ambien (zolpidem tartrate), especially for people who are female, 60+ old, also take Nexium, and have High blood pressure.

The phase IV clinical study analyzes which people have Angle closure glaucoma when taking Ambien. It is created by eHealthMe based on reports of 86,763 people who have side effects when taking Ambien from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Angle closure glaucoma?

Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity) is found to be associated with 206 drugs and 481 conditions by eHealthMe. Check the latest studies of Angle closure glaucoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

86,763 people reported to have side effects when taking Ambien.
Among them, 20 people (0.02%) have Angle closure glaucoma.

Could Ambien cause Angle closure glaucoma?

Among these 20 people:

What is the gender of people who have Angle closure glaucoma when taking Ambien? *

female: 90 %
male: 10 %

What is the age of people who have Angle closure glaucoma when taking Ambien? *

What are other drugs people take besides Ambien? *

What are other side effects people have besides Angle closure glaucoma? *

Cataract (clouding of the lens inside the eye): 4 people, 20.00%
Eye Pain: 4 people, 20.00%
Headache (pain in head): 3 people, 15.00%
Visual Impairment: 3 people, 15.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 15.00%
Nausea And Vomiting: 3 people, 15.00%
Nausea (feeling of having an urge to vomit): 3 people, 15.00%
Dyspnea (difficult or laboured breathing): 3 people, 15.00%
Episcleritis (acute inflammatory disorder of the episclera of eye): 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%

What are the existing conditions these people have? *

Stress And Anxiety: 4 people, 20.00%
High Blood Pressure: 4 people, 20.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 15.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 15.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 15.00%
High Blood Cholesterol: 3 people, 15.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Dyspnea (difficult or laboured breathing): 2 people, 10.00%
Ovarian Cancer (cancer of ovary): 2 people, 10.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Ambien and have Angle closure glaucoma?

- Check whether Angle closure glaucoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ambien:

Ambien (93,519 reports)

Browse all side effects of Ambien:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angle closure glaucoma:

Angle closure glaucoma (206 drugs)

Browse all the conditions that are associated with Angle closure glaucoma:

Angle closure glaucoma (481 conditions)

Related publications that referenced our studies

Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .
Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on zolpidem tartrate (the active ingredients of Ambien) and Ambien (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.