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Ambien and Calcinosis - a phase IV clinical study of FDA data

Summary:

Calcinosis is reported as a side effect among people who take Ambien (zolpidem tartrate), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Oxycontin, and have Pain.

The phase IV clinical study analyzes which people have Calcinosis when taking Ambien. It is created by eHealthMe based on reports of 86,763 people who have side effects when taking Ambien from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,516 Ambien users. Check the latest studies of Ambien.

What is Calcinosis?

Calcinosis (calcium deposits in any soft tissue) is found to be associated with 501 drugs and 857 conditions by eHealthMe. Check the latest studies of Calcinosis.

On Feb, 01, 2026

86,763 people reported to have side effects when taking Ambien.
Among them, 41 people (0.05%) have Calcinosis.

Could Ambien cause Calcinosis?

Among these 41 people:

How long have people been on Ambien when they have Calcinosis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 100 %
  • 10+ years: 0.0 %

What is the gender of people who have Calcinosis when taking Ambien? *

  • female: 63.41 %
  • male: 36.59 %

What is the age of people who have Calcinosis when taking Ambien? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 13.79 %
  • 40-49: 6.9 %
  • 50-59: 41.38 %
  • 60+: 37.93 %

What are other drugs people take besides Ambien? *

  1. Oxycontin: 14 people, 34.15%
  2. Prilosec: 13 people, 31.71%
  3. Neurontin: 12 people, 29.27%
  4. Ativan: 12 people, 29.27%
  5. Levaquin: 11 people, 26.83%
  6. Celexa: 10 people, 24.39%
  7. Vancomycin: 10 people, 24.39%
  8. Zofran: 9 people, 21.95%
  9. Rocephin: 9 people, 21.95%
  10. Demerol: 8 people, 19.51%

What are other side effects people have besides Calcinosis? *

  1. Stress And Anxiety: 15 people, 36.59%
  2. Joint Pain: 13 people, 31.71%
  3. Depression: 13 people, 31.71%
  4. Fall: 13 people, 31.71%
  5. Dyspnea (difficult or laboured breathing): 11 people, 26.83%
  6. Fatigue (feeling of tiredness): 11 people, 26.83%
  7. Drug Dependence: 11 people, 26.83%
  8. Headache (pain in head): 10 people, 24.39%
  9. High Blood Pressure: 10 people, 24.39%
  10. Oedema Peripheral (superficial swelling): 10 people, 24.39%

What are the existing conditions these people have? *

  1. Pain: 7 people, 17.07%
  2. Multiple Myeloma (cancer of the plasma cells): 4 people, 9.76%
  3. Depression: 3 people, 7.32%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.32%
  5. Muscle Spasms (muscle contraction): 3 people, 7.32%
  6. Upper Respiratory Tract Infection: 2 people, 4.88%
  7. High Blood Pressure: 2 people, 4.88%
  8. Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 2 people, 4.88%
  9. Osteoporosis (bones weak and more likely to break): 2 people, 4.88%
  10. Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 2 people, 4.88%

* Approximation only. Some reports may have incomplete information.

Do you take Ambien and have Calcinosis?

- Check whether Calcinosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ambien:

Calcinosis treatments and more:

How severe was Calcinosis and when was it recovered:

Expand to all the drugs that have ingredients of zolpidem tartrate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ambien:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Calcinosis:

Browse all the conditions that are associated with Calcinosis:

Drugs similar to Ambien and Calcinosis :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on zolpidem tartrate (the active ingredients of Ambien) and Ambien (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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