Ambien and Hepatojugular reflux - a phase IV clinical study of FDA data

Summary:

Hepatojugular reflux is reported as a side effect among people who take Ambien (zolpidem tartrate), especially for people who are male, 40-49 old, also take Coreg, and have Heart rate irregular.

The phase IV clinical study analyzes which people have Hepatojugular reflux when taking Ambien. It is created by eHealthMe based on reports of 86,763 people who have side effects when taking Ambien from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Hepatojugular reflux?

Hepatojugular reflux (a venous reflux occurring in congestive heart failure) is found to be associated with 69 drugs and 114 conditions by eHealthMe. Check the latest studies of Hepatojugular reflux.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

86,763 people reported to have side effects when taking Ambien.
Among them, 12 people (0.01%) have Hepatojugular reflux.

Could Ambien cause Hepatojugular reflux?

Among these 12 people:

What is the gender of people who have Hepatojugular reflux when taking Ambien? *

female: 0.0 %
male: 100 %

What is the age of people who have Hepatojugular reflux when taking Ambien? *

What are other drugs people take besides Ambien? *

What are other side effects people have besides Hepatojugular reflux? *

Jugular Vein Distension (overloaded jugular vein): 11 people, 91.67%
Cholecystitis Acute (rapid infection of gallbladder): 10 people, 83.33%
Fatigue (feeling of tiredness): 9 people, 75.00%
Diarrhea: 9 people, 75.00%
Blood Glucose Increased: 9 people, 75.00%
Hypotension (abnormally low blood pressure): 9 people, 75.00%
Atrioventricular Block First Degree (heart block first degree): 9 people, 75.00%
Aortic Valve Calcification: 9 people, 75.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 75.00%
Acute Kidney Failure: 9 people, 75.00%

What are the existing conditions these people have? *

Heart Rate Irregular: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ambien and have Hepatojugular reflux?

- Check whether Hepatojugular reflux is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ambien:

Ambien (93,519 reports)

Browse all side effects of Ambien:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatojugular reflux:

Hepatojugular reflux (69 drugs)

Browse all the conditions that are associated with Hepatojugular reflux:

Hepatojugular reflux (114 conditions)

Related publications that referenced our studies

Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .
Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on zolpidem tartrate (the active ingredients of Ambien) and Ambien (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.