Ambien and Otitis externa - a phase IV clinical study of FDA data


We study 85,358 people who have side effects when taking Ambien. Otitis externa is found, especially among people who are female, 60+ old, also take Synthroid and have Osteoporosis.

The phase IV clinical study analyzes which people take Ambien and have Otitis externa. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

85,358 people reported to have side effects when taking Ambien.
Among them, 92 people (0.11%) have Otitis externa.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is used in insomnia. Currently, eHealthMe is studying from 92,052 Ambien users.

What is Otitis externa?

Otitis externa (external ear infection) is found to be associated with 1,026 drugs and 401 conditions by eHealthMe. Currently, we are studying 2,429 people who have Otitis externa.

Number of Ambien and Otitis externa reports submitted per year:

Could Ambien cause Otitis externa?

Gender of people who have Otitis externa when taking Ambien *:

  • female: 85.39 %
  • male: 14.61 %

Age of people who have Otitis externa when taking Ambien *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.2 %
  • 20-29: 0.0 %
  • 30-39: 4.82 %
  • 40-49: 13.25 %
  • 50-59: 26.51 %
  • 60+: 54.22 %

Common drugs people take besides Ambien *:

  1. Synthroid: 38 people, 41.30%
  2. Cytoxan: 37 people, 40.22%
  3. Zometa: 36 people, 39.13%
  4. Vioxx: 34 people, 36.96%
  5. Zofran: 34 people, 36.96%
  6. Aredia: 32 people, 34.78%
  7. Levaquin: 31 people, 33.70%
  8. Vicodin: 31 people, 33.70%
  9. Lasix: 31 people, 33.70%
  10. Prilosec: 29 people, 31.52%

Common side effects people have besides Otitis externa *:

  1. Osteomyelitis (infection of bone): 57 people, 61.96%
  2. Fatigue (feeling of tiredness): 54 people, 58.70%
  3. Sinusitis (inflammation of sinus): 54 people, 58.70%
  4. Weight Decreased: 53 people, 57.61%
  5. Spinal Osteoarthritis (joint cartilage loss in spine): 52 people, 56.52%
  6. Osteonecrosis Of Jaw (death of bone of jaw): 45 people, 48.91%
  7. Neck Pain: 43 people, 46.74%
  8. Joint Pain: 42 people, 45.65%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 41 people, 44.57%
  10. Stress And Anxiety: 40 people, 43.48%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 36 people, 39.13%
  2. Arthritis (form of joint disorder that involves inflammation of one or more joints): 25 people, 27.17%
  3. Osteopenia (a condition where bone mineral density is lower than normal): 19 people, 20.65%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 17 people, 18.48%
  5. Breast Cancer Metastatic: 11 people, 11.96%
  6. Breast Cancer: 10 people, 10.87%
  7. Fungal Infection: 10 people, 10.87%
  8. Pain: 7 people, 7.61%
  9. Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 4.35%
  10. Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Ambien and have Otitis externa?

Check whether Otitis externa is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Ambien side effects by duration, gender and age:

Otitis externa treatments and more:

Common drugs associated with Otitis externa:

All the drugs that are associated with Otitis externa:

Common conditions associated with Otitis externa:

All the conditions that are associated with Otitis externa:

How the study uses the data?

The study uses data from the FDA. It is based on zolpidem tartrate (the active ingredients of Ambien) and Ambien (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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