Amitiza and Bradycardia - a phase IV clinical study of FDA data

Summary:

Bradycardia is reported as a side effect among people who take Amitiza (lubiprostone), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Fish Oil, and have Metastases to central nervous system.

The phase IV clinical study analyzes which people have Bradycardia when taking Amitiza. It is created by eHealthMe based on reports of 10,225 people who have side effects when taking Amitiza from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Bradycardia?

Bradycardia (abnormally slow heart action) is found to be associated with 1,926 drugs and 3,118 conditions by eHealthMe. Check the latest studies of Bradycardia.

On Jul, 22, 2026

10,225 people reported to have side effects when taking Amitiza.
Among them, 29 people (0.28%) have Bradycardia.

Among these 29 people:

How long have people been on Amitiza when they have Bradycardia? *

What is the gender of people who have Bradycardia when taking Amitiza? *

female: 77.78 %
male: 22.22 %

What is the age of people who have Bradycardia when taking Amitiza? *

What are other drugs people take besides Amitiza? *

What are other side effects people have besides Bradycardia? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 12 people, 41.38%
Fatigue (feeling of tiredness): 11 people, 37.93%
High Blood Pressure: 10 people, 34.48%
Nausea (feeling of having an urge to vomit): 10 people, 34.48%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 31.03%
Pain: 8 people, 27.59%
Dyspnea (difficult or laboured breathing): 8 people, 27.59%
Insomnia (sleeplessness): 7 people, 24.14%
Memory Loss: 7 people, 24.14%
Acute Kidney Failure: 6 people, 20.69%

What are the existing conditions these people have? *

Metastases To Central Nervous System (cancer spreads to central nervous system): 5 people, 17.24%
Lung Neoplasm Malignant (cancer tumour of lung): 4 people, 13.79%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 10.34%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.34%
Neoplasm Malignant (cancer tumour): 3 people, 10.34%
Type 2 Diabetes: 2 people, 6.90%
Depression: 2 people, 6.90%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 6.90%
Hepatocellular Carcinoma (liver cancer): 2 people, 6.90%
Paraparesis (partial paralysis of the lower limbs): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Amitiza and have Bradycardia?

- Check whether Bradycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitiza:

Amitiza (10,567 reports)

Bradycardia treatments and more:

Bradycardia (61,180 reports)

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bradycardia:

Bradycardia (1,926 drugs)

Browse all the conditions that are associated with Bradycardia:

Bradycardia (3,118 conditions)

Related publications that referenced our studies

Schlumbrecht MP, Hehr K, "Cisplatin-induced bradycardia and the importance of the QT interval", Journal of Oncology Pharmacy Practice, 2015 Jan .
Oflaz MB, Kucukdurmaz Z, Guven AS, Karapinar H, Kaya A, Sancakdar E, Deveci K, Gul I, Erdem A, Cevit O, Icagasioglu FD, "Bradycardia seen in children with Crimean-Congo hemorrhagic fever", Vector-Borne and Zoonotic Diseases, 2013 Nov .
Schlumbrecht MP, Hehr K, "Cisplatin-induced bradycardia and the importance of the QT interval", Journal of Oncology Pharmacy Practice, 2015 Jan .
Oflaz MB, Kucukdurmaz Z, Guven AS, Karapinar H, Kaya A, Sancakdar E, Deveci K, Gul I, Erdem A, Cevit O, Icagasioglu FD, "Bradycardia seen in children with Crimean-Congo hemorrhagic fever", Vector-Borne and Zoonotic Diseases, 2013 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on lubiprostone (the active ingredients of Amitiza) and Amitiza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.