Amitiza and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Amitiza (lubiprostone), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Lyrica, and have Narcolepsy.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Amitiza. It is created by eHealthMe based on reports of 10,225 people who have side effects when taking Amitiza from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 954 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 17, 2026

10,225 people reported to have side effects when taking Amitiza.
Among them, 17 people (0.17%) have Knee joint replacement.

Could Amitiza cause Knee joint replacement?

Among these 17 people:

How long have people been on Amitiza when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Amitiza? *

female: 100 %
male: 0.0 %

What is the age of people who have Knee joint replacement when taking Amitiza? *

What are other drugs people take besides Amitiza? *

What are other side effects people have besides Knee joint replacement? *

Neuralgia (pain in one or more nerves): 4 people, 23.53%
Urinary Tract Infection: 4 people, 23.53%
Joint Stiffness: 3 people, 17.65%
Dyspnea (difficult or laboured breathing): 3 people, 17.65%
Fall: 3 people, 17.65%
Gait Disturbance: 3 people, 17.65%
Peripheral Swelling: 3 people, 17.65%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 17.65%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 3 people, 17.65%
Joint Swelling: 3 people, 17.65%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 35.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
High Blood Pressure: 3 people, 17.65%
Asthma: 2 people, 11.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.76%
Drowsiness: 2 people, 11.76%
Nausea (feeling of having an urge to vomit): 2 people, 11.76%
Migraine (headache): 2 people, 11.76%
Joint Pain: 2 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Amitiza and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitiza:

Amitiza (10,567 reports)

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (954 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lubiprostone (the active ingredients of Amitiza) and Amitiza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.