Amitiza and Muscle twitching - a phase IV clinical study of FDA data

Summary:

Muscle twitching is reported as a side effect among people who take Amitiza (lubiprostone), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Fluoxetine, and have Impaired gastric emptying.

The phase IV clinical study analyzes which people have Muscle twitching when taking Amitiza. It is created by eHealthMe based on reports of 10,225 people who have side effects when taking Amitiza from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Muscle twitching?

Muscle twitching is found to be associated with 1,240 drugs and 1,905 conditions by eHealthMe. Check the latest studies of Muscle twitching.



On Jul, 27, 2026

10,225 people reported to have side effects when taking Amitiza.
Among them, 19 people (0.19%) have Muscle twitching.

Could Amitiza cause Muscle twitching?

Among these 19 people:

How long have people been on Amitiza when they have Muscle twitching? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Muscle twitching when taking Amitiza? *

  • female: 94.74 %
  • male: 5.26 %

What is the age of people who have Muscle twitching when taking Amitiza? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 14.29 %
  • 20-29: 0.0 %
  • 30-39: 14.29 %
  • 40-49: 21.43 %
  • 50-59: 28.57 %
  • 60+: 21.43 %

What are other drugs people take besides Amitiza? *

  1. Lyrica: 5 people, 26.32%
  2. Protonix: 5 people, 26.32%
  3. Fluoxetine: 5 people, 26.32%
  4. Prilosec: 4 people, 21.05%
  5. Metoclopramide: 4 people, 21.05%
  6. Ambien: 4 people, 21.05%
  7. Flonase: 3 people, 15.79%
  8. Fish Oil: 3 people, 15.79%
  9. Miralax: 3 people, 15.79%
  10. Metronidazole: 3 people, 15.79%

What are other side effects people have besides Muscle twitching? *

  1. Nausea (feeling of having an urge to vomit): 10 people, 52.63%
  2. Fatigue (feeling of tiredness): 8 people, 42.11%
  3. Headache (pain in head): 7 people, 36.84%
  4. Diarrhea: 6 people, 31.58%
  5. Pain: 6 people, 31.58%
  6. Weight Decreased: 6 people, 31.58%
  7. Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 31.58%
  8. Nausea And Vomiting: 6 people, 31.58%
  9. Dizziness: 5 people, 26.32%
  10. Abdominal Distension: 5 people, 26.32%

What are the existing conditions these people have? *

  1. Migraine (headache): 3 people, 15.79%
  2. Impaired Gastric Emptying: 3 people, 15.79%
  3. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 10.53%
  4. Pain: 2 people, 10.53%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
  6. Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 1 person, 5.26%
  7. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.26%
  8. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 5.26%
  9. Depression: 1 person, 5.26%
  10. Eye Disorder: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Amitiza and have Muscle twitching?

- Check whether Muscle twitching is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitiza:

Muscle twitching treatments and more:

How severe was Muscle twitching and when was it recovered:

Expand to all the drugs that have ingredients of lubiprostone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle twitching:

Browse all the conditions that are associated with Muscle twitching:


How the study uses the data?

The study uses data from the FDA. It is based on lubiprostone (the active ingredients of Amitiza) and Amitiza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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