Amitiza and Urinary incontinence - a phase IV clinical study of FDA data

Summary:

Urinary incontinence is reported as a side effect among people who take Amitiza (lubiprostone), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin B12, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Urinary incontinence when taking Amitiza. It is created by eHealthMe based on reports of 10,225 people who have side effects when taking Amitiza from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Urinary incontinence?

Urinary incontinence (inability to control the flow of urine and involuntary urination) is found to be associated with 1,637 drugs and 2,517 conditions by eHealthMe. Check the latest studies of Urinary incontinence.

On Apr, 26, 2026

10,225 people reported to have side effects when taking Amitiza.
Among them, 71 people (0.69%) have Urinary incontinence.

Could Amitiza cause Urinary incontinence?

Among these 71 people:

How long have people been on Amitiza when they have Urinary incontinence? *

What is the gender of people who have Urinary incontinence when taking Amitiza? *

female: 88.52 %
male: 11.48 %

What is the age of people who have Urinary incontinence when taking Amitiza? *

What are other drugs people take besides Amitiza? *

What are other side effects people have besides Urinary incontinence? *

Fatigue (feeling of tiredness): 34 people, 47.89%
Weakness: 30 people, 42.25%
Headache (pain in head): 30 people, 42.25%
Dizziness: 25 people, 35.21%
Pain: 23 people, 32.39%
Depression: 22 people, 30.99%
Joint Pain: 21 people, 29.58%
Muscle Aches (muscle pain): 20 people, 28.17%
Diarrhea: 20 people, 28.17%
Tremor (trembling or shaking movements in one or more parts of your body): 20 people, 28.17%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 17 people, 23.94%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 18.31%
Primary Myelofibrosis (primary disorder of the bone marrow): 10 people, 14.08%
Pain: 9 people, 12.68%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 12.68%
Cough: 7 people, 9.86%
Gait Disturbance: 7 people, 9.86%
Urethritis Noninfective (inflammation of the urethra - non infective): 7 people, 9.86%
Bladder Disorder: 7 people, 9.86%
Blood Glucose Abnormal: 7 people, 9.86%

* Approximation only. Some reports may have incomplete information.

Do you take Amitiza and have Urinary incontinence?

- Check whether Urinary incontinence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitiza:

Amitiza (10,567 reports)

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Urinary incontinence:

Urinary incontinence (1,637 drugs)

Browse all the conditions that are associated with Urinary incontinence:

Urinary incontinence (2,517 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lubiprostone (the active ingredients of Amitiza) and Amitiza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.