Amitriptyline hydrochloride and Muscle function loss - a phase IV clinical study of FDA data

Summary:

Muscle function loss is reported as a side effect among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride), especially for people who are female, 30-39 old, also take Mirtazapine, and have Extrapyramidal disorder.

The phase IV clinical study analyzes which people have Muscle function loss when taking Amitriptyline hydrochloride. It is created by eHealthMe based on reports of 16,582 people who have side effects when taking Amitriptyline hydrochloride from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Muscle function loss?

Muscle function loss is found to be associated with 1,001 drugs and 1,521 conditions by eHealthMe. Check the latest studies of Muscle function loss.

On Jul, 26, 2026

16,582 people reported to have side effects when taking Amitriptyline hydrochloride.
Among them, 67 people (0.4%) have Muscle function loss.

Could Amitriptyline hydrochloride cause Muscle function loss?

Among these 67 people:

What is the gender of people who have Muscle function loss when taking Amitriptyline hydrochloride? *

female: 85.07 %
male: 14.93 %

What is the age of people who have Muscle function loss when taking Amitriptyline hydrochloride? *

What are other drugs people take besides Amitriptyline hydrochloride? *

Omeprazole: 35 people, 52.24%
Mirtazapine: 35 people, 52.24%
Clonazepam: 34 people, 50.75%
Lorazepam: 33 people, 49.25%
Diazepam: 33 people, 49.25%
Paroxetine Hydrochloride: 32 people, 47.76%
Tramadol Hydrochloride: 28 people, 41.79%
Paroxetine: 26 people, 38.81%
Quetiapine Fumarate: 23 people, 34.33%
Codeine: 20 people, 29.85%

What are other side effects people have besides Muscle function loss? *

Hypoaesthesia (reduced sense of touch or sensation): 51 people, 76.12%
Muscle Spasms (muscle contraction): 50 people, 74.63%
Fatigue (feeling of tiredness): 50 people, 74.63%
Dizziness: 48 people, 71.64%
Gait Disturbance: 47 people, 70.15%
Drowsiness: 47 people, 70.15%
Speech Impairment (Adult) (inability to speak (adult)): 47 people, 70.15%
Joint Pain: 46 people, 68.66%
Confusion: 46 people, 68.66%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 46 people, 68.66%

What are the existing conditions these people have? *

Sedation: 44 people, 65.67%
Indigestion: 44 people, 65.67%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 44 people, 65.67%
Psychotic Disorder: 43 people, 64.18%
Muscle Spasms (muscle contraction): 42 people, 62.69%
Neuralgia (pain in one or more nerves): 40 people, 59.70%
Neck Pain: 40 people, 59.70%
Post-Traumatic Stress Disorder: 39 people, 58.21%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 38 people, 56.72%
Oculogyric Crisis (a spasmodic movement of the eyeballs into a fixed position due to medicine reaction): 38 people, 56.72%

* Approximation only. Some reports may have incomplete information.

Do you take Amitriptyline hydrochloride and have Muscle function loss?

- Check whether Muscle function loss is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitriptyline hydrochloride:

Amitriptyline hydrochloride (20,054 reports)

Browse all side effects of Amitriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle function loss:

Muscle function loss (1,001 drugs)

Browse all the conditions that are associated with Muscle function loss:

Muscle function loss (1,521 conditions)

Related publications that referenced our studies

Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Amitriptyline hydrochloride) and Amitriptyline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.