Amnesteem and Cannot sleep - a phase IV clinical study of FDA data

Summary:

Cannot sleep is reported as a side effect among people who take Amnesteem (isotretinoin), especially for people who are female, 10-19 old, have been taking the drug for 1 - 6 months also take Accutane, and have Eczema.

The phase IV clinical study analyzes which people have Cannot sleep when taking Amnesteem. It is created by eHealthMe based on reports of 7,301 people who have side effects when taking Amnesteem from the FDA, and is updated regularly.

What is Amnesteem?

Amnesteem has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 7,344 Amnesteem users. Check the latest studies of Amnesteem.

What is Cannot sleep?

Cannot sleep is found to be associated with 4,473 drugs and 5,378 conditions by eHealthMe. Check the latest studies of Cannot sleep.

On Jun, 16, 2026

7,301 people reported to have side effects when taking Amnesteem.
Among them, 82 people (1.12%) have Cannot sleep.

Among these 82 people:

How long have people been on Amnesteem when they have Cannot sleep? *

What is the gender of people who have Cannot sleep when taking Amnesteem? *

female: 59.26 %
male: 40.74 %

What is the age of people who have Cannot sleep when taking Amnesteem? *

What are other drugs people take besides Amnesteem? *

What are other side effects people have besides Cannot sleep? *

Depression: 34 people, 41.46%
Stress And Anxiety: 24 people, 29.27%
Suicidal Ideation: 22 people, 26.83%
Inflammatory Bowel Disease: 21 people, 25.61%
Headache (pain in head): 14 people, 17.07%
Joint Pain: 13 people, 15.85%
Irritability: 12 people, 14.63%
Fatigue (feeling of tiredness): 11 people, 13.41%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 13.41%
Haemorrhage (bleeding): 10 people, 12.20%

What are the existing conditions these people have? *

Sinusitis (inflammation of sinus): 3 people, 3.66%
Pain: 3 people, 3.66%
Laryngitis (inflammation of the larynx): 3 people, 3.66%
Irritable Bowel Syndrome: 3 people, 3.66%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 3.66%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 3.66%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 1.22%
Depression: 1 person, 1.22%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 1.22%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 1.22%

* Approximation only. Some reports may have incomplete information.

Do you take Amnesteem and have Cannot sleep?

- Check whether Cannot sleep is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amnesteem:

Amnesteem (7,344 reports)

Cannot sleep treatments and more:

Cannot sleep (438,076 reports)

Browse all side effects of Amnesteem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cannot sleep:

Cannot sleep (4,473 drugs)

Browse all the conditions that are associated with Cannot sleep:

Cannot sleep (5,378 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Amnesteem) and Amnesteem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.