Amnesteem and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Amnesteem (isotretinoin), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Differin, and have Premenstrual syndrome.

The phase IV clinical study analyzes which people have Heart attack when taking Amnesteem. It is created by eHealthMe based on reports of 7,301 people who have side effects when taking Amnesteem from the FDA, and is updated regularly.

What is Amnesteem?

Amnesteem has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 7,344 Amnesteem users. Check the latest studies of Amnesteem.

What is Heart attack?

Heart attack is found to be associated with 2,512 drugs and 3,290 conditions by eHealthMe. Check the latest studies of Heart attack.

On Apr, 30, 2026

7,301 people reported to have side effects when taking Amnesteem.
Among them, 16 people (0.22%) have Heart attack.

Among these 16 people:

How long have people been on Amnesteem when they have Heart attack? *

What is the gender of people who have Heart attack when taking Amnesteem? *

female: 60 %
male: 40 %

What is the age of people who have Heart attack when taking Amnesteem? *

What are other drugs people take besides Amnesteem? *

What are other side effects people have besides Heart attack? *

Dyspnea (difficult or laboured breathing): 5 people, 31.25%
Mobility Decreased (ability to move is reduced): 4 people, 25.00%
Fainting (loss of consciousness and postural tone): 4 people, 25.00%
Chest Pain: 4 people, 25.00%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 2 people, 12.50%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 6.25%
Hypoaesthesia (reduced sense of touch or sensation): 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%
Headache (pain in head): 1 person, 6.25%
Eye Pruritus (eye itching): 1 person, 6.25%

What are the existing conditions these people have? *

Prostate Cancer: 2 people, 12.50%
Premenstrual Syndrome: 2 people, 12.50%
Sebaceous Hyperplasia (a disorder of the sebaceous glands in which they become enlarged): 1 person, 6.25%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Amnesteem and have Heart attack?

- Check whether Heart attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amnesteem:

Amnesteem (7,344 reports)

Heart attack treatments and more:

Heart attack (266,142 reports)

Browse all side effects of Amnesteem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Heart attack (2,512 drugs)

Browse all the conditions that are associated with Heart attack:

Heart attack (3,290 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Amnesteem) and Amnesteem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.