Amnesteem and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Amnesteem (isotretinoin), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Accutane, and have Cataplexy.

The phase IV clinical study analyzes which people have Major depression when taking Amnesteem. It is created by eHealthMe based on reports of 7,301 people who have side effects when taking Amnesteem from the FDA, and is updated regularly.

What is Amnesteem?

Amnesteem has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 7,344 Amnesteem users. Check the latest studies of Amnesteem.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 798 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 24, 2026

7,301 people reported to have side effects when taking Amnesteem.
Among them, 14 people (0.19%) have Major depression.

Among these 14 people:

How long have people been on Amnesteem when they have Major depression? *

What is the gender of people who have Major depression when taking Amnesteem? *

female: 46.15 %
male: 53.85 %

What is the age of people who have Major depression when taking Amnesteem? *

What are other drugs people take besides Amnesteem? *

Accutane: 8 people, 57.14%
Methylphenidate: 3 people, 21.43%
Atomoxetine Hydrochloride: 3 people, 21.43%
Auvi-Q: 3 people, 21.43%
Doxycycline: 3 people, 21.43%
Epinephrine: 3 people, 21.43%
Epipen: 3 people, 21.43%
Flonase Allergy Relief: 3 people, 21.43%
Fluoxetine: 3 people, 21.43%
Inderal La: 3 people, 21.43%

What are other side effects people have besides Major depression? *

Suicidal Ideation: 7 people, 50.00%
Depression: 5 people, 35.71%
Agitation (state of anxiety or nervous excitement): 5 people, 35.71%
Irritability: 4 people, 28.57%
Abnormal Behavior: 4 people, 28.57%
Mood Swings (an extreme or rapid change in mood): 4 people, 28.57%
Skin Papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections): 3 people, 21.43%
Precocious Puberty: 3 people, 21.43%
Social Avoidant Behavior: 3 people, 21.43%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 3 people, 21.43%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 21.43%
Dry Skin: 2 people, 14.29%
Drowsiness: 2 people, 14.29%
Depression: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Amnesteem and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amnesteem:

Amnesteem (7,344 reports)

Major depression treatments and more:

Major depression (44,987 reports)

Browse all side effects of Amnesteem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (798 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,477 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Amnesteem) and Amnesteem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.