Apidra and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Apidra (insulin glulisine recombinant), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Lantus, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Fluid retention when taking Apidra. It is created by eHealthMe based on reports of 10,479 people who have side effects when taking Apidra from the FDA, and is updated regularly.

What is Apidra?

Apidra has active ingredients of insulin glulisine recombinant. It is often used in diabetes. eHealthMe is studying from 10,548 Apidra users. Check the latest studies of Apidra.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,702 drugs and 2,446 conditions by eHealthMe. Check the latest studies of Fluid retention.

On Aug, 03, 2026

10,479 people reported to have side effects when taking Apidra.
Among them, 27 people (0.26%) have Fluid retention.

Among these 27 people:

How long have people been on Apidra when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Apidra? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Fluid retention when taking Apidra? *

What are other drugs people take besides Apidra? *

What are other side effects people have besides Fluid retention? *

Dyspnea (difficult or laboured breathing): 10 people, 37.04%
Blood Glucose Increased: 10 people, 37.04%
Nausea And Vomiting: 6 people, 22.22%
Peripheral Swelling: 6 people, 22.22%
Weight Increased: 6 people, 22.22%
Abdominal Distension: 5 people, 18.52%
Hyperglycemia (high blood sugar): 4 people, 14.81%
Cardiac Failure Congestive: 4 people, 14.81%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 14.81%
Weakness: 4 people, 14.81%

What are the existing conditions these people have? *

Type 2 Diabetes: 10 people, 37.04%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 11.11%
High Blood Pressure: 3 people, 11.11%
High Blood Cholesterol: 3 people, 11.11%
Thyroid Diseases: 2 people, 7.41%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 7.41%
Gastric Disorder (disease of stomach): 2 people, 7.41%
Renal Disorder (kidney disease): 1 person, 3.70%
Muscle Spasms (muscle contraction): 1 person, 3.70%
Hyperkalemia (damage to or disease of the kidney): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Apidra and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Apidra:

Apidra (10,548 reports)

Fluid retention treatments and more:

Fluid retention (79,660 reports)

Browse all side effects of Apidra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,702 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,446 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on insulin glulisine recombinant (the active ingredients of Apidra) and Apidra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.