Apixaban and Brain midline shift - a phase IV clinical study of FDA data

Summary:

Brain midline shift is reported as a side effect among people who take Apixaban (apixaban), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Paracetamol, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Brain midline shift when taking Apixaban. It is created by eHealthMe based on reports of 60,044 people who have side effects when taking Apixaban from the FDA, and is updated regularly.

What is Apixaban?

Apixaban has active ingredients of apixaban. It is often used in blood clots. eHealthMe is studying from 60,351 Apixaban users. Check the latest studies of Apixaban.

What is Brain midline shift?

Brain midline shift is found to be associated with 85 drugs and 214 conditions by eHealthMe. Check the latest studies of Brain midline shift.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

60,044 people reported to have side effects when taking Apixaban.
Among them, 43 people (0.07%) have Brain midline shift.

Could Apixaban cause Brain midline shift?

Among these 43 people:

How long have people been on Apixaban when they have Brain midline shift? *

What is the gender of people who have Brain midline shift when taking Apixaban? *

female: 70.73 %
male: 29.27 %

What is the age of people who have Brain midline shift when taking Apixaban? *

What are other drugs people take besides Apixaban? *

What are other side effects people have besides Brain midline shift? *

Subdural Haematoma (blood collects between the skull and the surface of the brain): 19 people, 44.19%
Cerebral Haemorrhage (bleeding within the brain): 10 people, 23.26%
Unresponsive To Stimuli: 9 people, 20.93%
Haemorrhage Intracranial (bleeding within the skull): 9 people, 20.93%
Intraventricular Haemorrhage (intraventricular bleeding): 6 people, 13.95%
Headache (pain in head): 5 people, 11.63%
Subarachnoid Haemorrhage (blood leaks into the space between two membranes that surround the brain): 5 people, 11.63%
Brain Herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull): 5 people, 11.63%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 5 people, 11.63%
Hydrocephalus (water on the brain): 4 people, 9.30%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 20.93%
Venous Thrombosis Limb (blood clot that forms in a vein in the limb): 8 people, 18.60%
Migraine (headache): 7 people, 16.28%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 11.63%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 1 person, 2.33%
High Blood Pressure: 1 person, 2.33%
Embolism Venous (embolus may pass into the arterial system): 1 person, 2.33%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Apixaban and have Brain midline shift?

- Check whether Brain midline shift is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Apixaban:

Apixaban (60,351 reports)

Browse all side effects of Apixaban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain midline shift:

Brain midline shift (85 drugs)

Browse all the conditions that are associated with Brain midline shift:

Brain midline shift (214 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on apixaban (the active ingredients of Apixaban) and Apixaban (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.