Apixaban and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Apixaban (apixaban), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Paracetamol, and have Stroke.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Apixaban. It is created by eHealthMe based on reports of 60,044 people who have side effects when taking Apixaban from the FDA, and is updated regularly.

What is Apixaban?

Apixaban has active ingredients of apixaban. It is often used in blood clots. eHealthMe is studying from 60,349 Apixaban users. Check the latest studies of Apixaban.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,116 drugs and 843 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On May, 06, 2026

60,044 people reported to have side effects when taking Apixaban.
Among them, 44 people (0.07%) have Sinus node dysfunction.

Could Apixaban cause Sinus node dysfunction?

Among these 44 people:

How long have people been on Apixaban when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Apixaban? *

female: 59.46 %
male: 40.54 %

What is the age of people who have Sinus node dysfunction when taking Apixaban? *

What are other drugs people take besides Apixaban? *

What are other side effects people have besides Sinus node dysfunction? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 13 people, 29.55%
Pneumonia: 9 people, 20.45%
Dyspnea Exertional: 6 people, 13.64%
Fever: 5 people, 11.36%
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue): 4 people, 9.09%
Haematoma (collection of blood outside the blood vessels): 4 people, 9.09%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 9.09%
Fall: 4 people, 9.09%
Hyperkalemia (damage to or disease of the kidney): 3 people, 6.82%
Dizziness: 3 people, 6.82%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 18 people, 40.91%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 20.45%
Colorectal Cancer Stage Iii (colon and rectal cancer spreads to lymph nodes): 5 people, 11.36%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 6.82%
High Blood Pressure: 3 people, 6.82%
Cerebral Haemorrhage (bleeding within the brain): 2 people, 4.55%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 4.55%
Lumbar Vertebral Fracture: 2 people, 4.55%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 2 people, 4.55%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Apixaban and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Apixaban:

Apixaban (60,349 reports)

Browse all side effects of Apixaban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,116 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (843 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on apixaban (the active ingredients of Apixaban) and Apixaban (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.