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Apokyn and Dystonia aggravated - a phase IV clinical study of FDA data

Summary:

Dystonia aggravated is reported as a side effect among people who take Apokyn (apomorphine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Rytary, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Dystonia aggravated when taking Apokyn. It is created by eHealthMe based on reports of 5,279 people who have side effects when taking Apokyn from the FDA, and is updated regularly.

What is Apokyn?

Apokyn has active ingredients of apomorphine hydrochloride. eHealthMe is studying from 5,284 Apokyn users. Check the latest studies of Apokyn.

What is Dystonia aggravated?

Dystonia aggravated (abnormal muscle tone) is found to be associated with 784 drugs and 282 conditions by eHealthMe. Check the latest studies of Dystonia aggravated.

On Jul, 14, 2026

5,279 people reported to have side effects when taking Apokyn.
Among them, 32 people (0.61%) have Dystonia aggravated.

Could Apokyn cause Dystonia aggravated?

Among these 32 people:

How long have people been on Apokyn when they have Dystonia aggravated? *

  • < 1 month: 60 %
  • 1 - 6 months: 40 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Dystonia aggravated when taking Apokyn? *

  • female: 56.25 %
  • male: 43.75 %

What is the age of people who have Dystonia aggravated when taking Apokyn? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.85 %
  • 40-49: 23.08 %
  • 50-59: 23.08 %
  • 60+: 50.0 %

What are other drugs people take besides Apokyn? *

  1. Sinemet: 10 people, 31.25%
  2. Rytary: 10 people, 31.25%
  3. Gocovri: 5 people, 15.62%
  4. Mirapex: 4 people, 12.50%
  5. Potassium: 3 people, 9.38%
  6. Cymbalta: 3 people, 9.38%
  7. Lipitor: 3 people, 9.38%
  8. Myrbetriq: 3 people, 9.38%
  9. Duopa: 3 people, 9.38%
  10. Lasix: 3 people, 9.38%

What are other side effects people have besides Dystonia aggravated? *

  1. Dyskinesia (abnormality or impairment of voluntary movement): 10 people, 31.25%
  2. Depression: 5 people, 15.62%
  3. Insomnia (sleeplessness): 5 people, 15.62%
  4. On And Off Phenomenon: 5 people, 15.62%
  5. Parkinson's Disease: 5 people, 15.62%
  6. Drowsiness: 4 people, 12.50%
  7. Dementia (madness): 3 people, 9.38%
  8. Nausea (feeling of having an urge to vomit): 3 people, 9.38%
  9. Muscle Twitching: 3 people, 9.38%
  10. Muscle Spasms (muscle contraction): 3 people, 9.38%

What are the existing conditions these people have? *

  1. Parkinson's Disease: 28 people, 87.50%
  2. Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 9.38%
  3. Stress And Anxiety: 1 person, 3.12%
  4. Muscle Aches (muscle pain): 1 person, 3.12%
  5. Depression: 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Apokyn and have Dystonia aggravated?

- Check whether Dystonia aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Apokyn:

Dystonia aggravated treatments and more:

How severe was Dystonia aggravated and when was it recovered:

Expand to all the drugs that have ingredients of apomorphine hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Apokyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dystonia aggravated:

Browse all the conditions that are associated with Dystonia aggravated:

How the study uses the data?

The study uses data from the FDA. It is based on apomorphine hydrochloride (the active ingredients of Apokyn) and Apokyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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