Aprepitant and Hypernatraemia - a phase IV clinical study of FDA data

Summary:

Hypernatraemia is reported as a side effect among people who take Aprepitant (aprepitant), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Ondansetron, and have Bone disorder.

The phase IV clinical study analyzes which people have Hypernatraemia when taking Aprepitant. It is created by eHealthMe based on reports of 6,989 people who have side effects when taking Aprepitant from the FDA, and is updated regularly.

What is Aprepitant?

Aprepitant has active ingredients of aprepitant. eHealthMe is studying from 6,992 Aprepitant users. Check the latest studies of Aprepitant.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 654 drugs and 805 conditions by eHealthMe. Check the latest studies of Hypernatraemia.

On Jun, 18, 2026

6,989 people reported to have side effects when taking Aprepitant.
Among them, 34 people (0.49%) have Hypernatraemia.

Among these 34 people:

How long have people been on Aprepitant when they have Hypernatraemia? *

What is the gender of people who have Hypernatraemia when taking Aprepitant? *

female: 89.29 %
male: 10.71 %

What is the age of people who have Hypernatraemia when taking Aprepitant? *

What are other drugs people take besides Aprepitant? *

Ondansetron: 26 people, 76.47%
Paracetamol: 20 people, 58.82%
Xgeva: 9 people, 26.47%
Acetaminophen: 7 people, 20.59%
Dexamethasone: 7 people, 20.59%
Chlorpheniramine Maleate: 6 people, 17.65%
Metoclopramide: 6 people, 17.65%
Hydrocortisone: 6 people, 17.65%
Nystatin: 5 people, 14.71%
Docetaxel: 5 people, 14.71%

What are other side effects people have besides Hypernatraemia? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 29 people, 85.29%
Malaise (a feeling of general discomfort or uneasiness): 27 people, 79.41%
Fatigue (feeling of tiredness): 27 people, 79.41%
Haematemesis (vomiting of blood): 26 people, 76.47%
Nausea (feeling of having an urge to vomit): 26 people, 76.47%
Hair Loss: 26 people, 76.47%
Pain In Jaw: 26 people, 76.47%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 26 people, 76.47%
Onychalgia (nail biting): 26 people, 76.47%
Dehydration (dryness resulting from the removal of water): 4 people, 11.76%

What are the existing conditions these people have? *

Bone Disorder: 26 people, 76.47%
Breast Cancer Metastatic: 22 people, 64.71%
Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 2 people, 5.88%
Itching: 2 people, 5.88%
Inappropriate Antidiuretic Hormone Secretion: 2 people, 5.88%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 2 people, 5.88%
Colon Cancer: 2 people, 5.88%
Urinary Tract Infection: 1 person, 2.94%
Pain: 1 person, 2.94%
Nodal Marginal Zone B-Cell Lymphoma (a type of blood cancer occurs within the lymph nodes): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Aprepitant and have Hypernatraemia?

- Check whether Hypernatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aprepitant:

Aprepitant (6,992 reports)

Hypernatraemia treatments and more:

Hypernatraemia (6,339 reports)

Browse all side effects of Aprepitant:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypernatraemia:

Hypernatraemia (654 drugs)

Browse all the conditions that are associated with Hypernatraemia:

Hypernatraemia (805 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aprepitant (the active ingredients of Aprepitant) and Aprepitant (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.