Arava and Hyperaesthesia - a phase IV clinical study of FDA data

Summary:

Hyperaesthesia is reported as a side effect among people who take Arava (leflunomide), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Cymbalta, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Hyperaesthesia when taking Arava. It is created by eHealthMe based on reports of 75,674 people who have side effects when taking Arava from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,039 Arava users. Check the latest studies of Arava.

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 932 drugs and 908 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

On Oct, 24, 2025

75,674 people reported to have side effects when taking Arava.
Among them, 111 people (0.15%) have Hyperaesthesia.

Among these 111 people:

How long have people been on Arava when they have Hyperaesthesia? *

What is the gender of people who have Hyperaesthesia when taking Arava? *

female: 96.77 %
male: 3.23 %

What is the age of people who have Hyperaesthesia when taking Arava? *

What are other drugs people take besides Arava? *

What are other side effects people have besides Hyperaesthesia? *

Pain: 98 people, 88.29%
Swelling: 89 people, 80.18%
Nasopharyngitis (inflammation of the nasopharynx): 89 people, 80.18%
Haemoglobin Decreased: 89 people, 80.18%
Weakness: 89 people, 80.18%
Fungal Infection: 88 people, 79.28%
Diarrhea: 88 people, 79.28%
Joint Pain: 49 people, 44.14%
Back Pain: 48 people, 43.24%
Fatigue (feeling of tiredness): 45 people, 40.54%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 6.31%
High Blood Pressure: 4 people, 3.60%
High Blood Cholesterol: 3 people, 2.70%
Birth Control: 2 people, 1.80%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 1 person, 0.90%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 0.90%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 0.90%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and have Hyperaesthesia?

- Check whether Hyperaesthesia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Arava:

Arava (76,039 reports)

Hyperaesthesia treatments and more:

Hyperaesthesia (10,827 reports)

Browse all side effects of Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hyperaesthesia:

Browse all the drugs that are associated with Hyperaesthesia:

Hyperaesthesia (932 drugs)

Common conditions associated with Hyperaesthesia:

Pain: 868 reports
Ms: 761 reports
Rheumatoid arthritis: 742 reports
Acupuncture and pain: 378 reports
Hypertension aggravated: 371 reports
Blood pressure increased: 370 reports
Depression: 304 reports
Antidepressant therapy: 303 reports
Blood triglycerides increased: 258 reports
Stress: 230 reports

Browse all the conditions that are associated with Hyperaesthesia:

Hyperaesthesia (908 conditions)

Drugs similar to Arava and Hyperaesthesia :

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Arava) and Arava (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.