Arava and Icterus - a phase IV clinical study of FDA data

Summary:

Icterus is reported as a side effect among people who take Arava (leflunomide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Methotrexate, and have High blood pressure.

The phase IV clinical study analyzes which people have Icterus when taking Arava. It is created by eHealthMe based on reports of 75,674 people who have side effects when taking Arava from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,039 Arava users. Check the latest studies of Arava.

What is Icterus?

Icterus (yellowish pigmentation of the skin) is found to be associated with 2,210 drugs and 2,985 conditions by eHealthMe. Check the latest studies of Icterus.

On Sep, 25, 2025

75,674 people reported to have side effects when taking Arava.
Among them, 165 people (0.22%) have Icterus.

Among these 165 people:

How long have people been on Arava when they have Icterus? *

What is the gender of people who have Icterus when taking Arava? *

female: 72.5 %
male: 27.5 %

What is the age of people who have Icterus when taking Arava? *

What are other drugs people take besides Arava? *

What are other side effects people have besides Icterus? *

Nausea And Vomiting: 55 people, 33.33%
Nausea (feeling of having an urge to vomit): 51 people, 30.91%
Alanine Aminotransferase Increased: 44 people, 26.67%
Blood Bilirubin Increased: 43 people, 26.06%
Aspartate Aminotransferase Increased: 42 people, 25.45%
Hepatitis (inflammation of the liver): 30 people, 18.18%
Blood Alkaline Phosphatase Increased: 29 people, 17.58%
Abdominal Pain: 27 people, 16.36%
Hepatotoxicity (chemical-driven liver damage): 25 people, 15.15%
Haematemesis (vomiting of blood): 24 people, 14.55%

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 6.67%
Osteoporosis (bones weak and more likely to break): 5 people, 3.03%
Heart Rate Irregular: 5 people, 3.03%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 2.42%
Pain: 3 people, 1.82%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 1.82%
Birth Control: 2 people, 1.21%
Asthma: 2 people, 1.21%
Polymyalgia Rheumatica (pain in many muscles): 2 people, 1.21%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 1.21%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and have Icterus?

- Check whether Icterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Arava:

Arava (76,039 reports)

Icterus treatments and more:

Icterus (33,621 reports)

Browse all side effects of Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Icterus:

Browse all the drugs that are associated with Icterus:

Icterus (2,210 drugs)

Common conditions associated with Icterus:

Hypertension: 2,055 reports
Human immunodeficiency virus infection: 1,000 reports
Hiv test: 978 reports
Hepatitis c: 954 reports
Pain exacerbated: 856 reports
Hypnosis and pain: 832 reports
Depression: 830 reports
Diabetes: 676 reports
Type 2 diabetes: 667 reports
Ra: 663 reports

Browse all the conditions that are associated with Icterus:

Icterus (2,985 conditions)

Drugs similar to Arava and Icterus :

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Arava) and Arava (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.