Arava and Intraocular pressure increased - a phase IV clinical study of FDA data

Summary:

Intraocular pressure increased is reported as a side effect among people who take Arava (leflunomide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Enbrel, and have Narcolepsy.

The phase IV clinical study analyzes which people have Intraocular pressure increased when taking Arava. It is created by eHealthMe based on reports of 75,674 people who have side effects when taking Arava from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Intraocular pressure increased?

Intraocular pressure increased is found to be associated with 716 drugs and 954 conditions by eHealthMe. Check the latest studies of Intraocular pressure increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

75,674 people reported to have side effects when taking Arava.
Among them, 86 people (0.11%) have Intraocular pressure increased.

Could Arava cause Intraocular pressure increased?

Among these 86 people:

How long have people been on Arava when they have Intraocular pressure increased? *

What is the gender of people who have Intraocular pressure increased when taking Arava? *

female: 98.78 %
male: 1.22 %

What is the age of people who have Intraocular pressure increased when taking Arava? *

What are other drugs people take besides Arava? *

What are other side effects people have besides Intraocular pressure increased? *

Weight Decreased: 64 people, 74.42%
Drug Ineffective: 63 people, 73.26%
Infection: 62 people, 72.09%
Drug Intolerance (drug sensitivity): 61 people, 70.93%
Ovarian Neoplasm (tumour of ovary): 60 people, 69.77%
Rashes (redness): 60 people, 69.77%
Pain: 34 people, 39.53%
Joint Swelling: 28 people, 32.56%
Eating Disorder: 27 people, 31.40%
Ocular Hypertension (intraocular pressure higher than normal): 27 people, 31.40%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 6.98%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 4.65%
Localised Infection (infection at the single location): 3 people, 3.49%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 2 people, 2.33%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 2.33%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 1.16%
High Blood Pressure: 1 person, 1.16%
Gastric Disorder (disease of stomach): 1 person, 1.16%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 1.16%
Birth Control: 1 person, 1.16%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and have Intraocular pressure increased?

- Check whether Intraocular pressure increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Arava:

Arava (76,040 reports)

Browse all side effects of Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intraocular pressure increased:

Intraocular pressure increased (716 drugs)

Browse all the conditions that are associated with Intraocular pressure increased:

Intraocular pressure increased (954 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Arava) and Arava (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.