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Arava and Nail abnormalities - a phase IV clinical study of FDA data

Summary:

Nail abnormalities is reported as a side effect among people who take Arava (leflunomide), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Enbrel, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Nail abnormalities when taking Arava. It is created by eHealthMe based on reports of 75,674 people who have side effects when taking Arava from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,039 Arava users. Check the latest studies of Arava.

What is Nail abnormalities?

Nail abnormalities (abnormal nail) is found to be associated with 233 drugs and 637 conditions by eHealthMe. Check the latest studies of Nail abnormalities.

On Oct, 14, 2025

75,674 people reported to have side effects when taking Arava.
Among them, 38 people (0.05%) have Nail abnormalities.

Could Arava cause Nail abnormalities?

Among these 38 people:

How long have people been on Arava when they have Nail abnormalities? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 66.67 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

What is the gender of people who have Nail abnormalities when taking Arava? *

  • female: 26.32 %
  • male: 73.68 %

What is the age of people who have Nail abnormalities when taking Arava? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 18.92 %
  • 60+: 81.08 %

What are other drugs people take besides Arava? *

  1. Enbrel: 27 people, 71.05%
  2. Taltz: 23 people, 60.53%
  3. Stelara: 23 people, 60.53%
  4. Pregabalin: 23 people, 60.53%
  5. Simponi: 23 people, 60.53%
  6. Lyrica: 23 people, 60.53%
  7. Humira: 23 people, 60.53%
  8. Amitriptyline Hydrochloride: 22 people, 57.89%
  9. Xeljanz: 21 people, 55.26%
  10. Cosentyx: 21 people, 55.26%

What are other side effects people have besides Nail abnormalities? *

  1. Gait Disturbance: 33 people, 86.84%
  2. Swelling: 30 people, 78.95%
  3. Pain: 29 people, 76.32%
  4. Renal Impairment (severely reduced kidney function): 26 people, 68.42%
  5. Rashes (redness): 24 people, 63.16%
  6. Psoriasis (immune-mediated disease that affects the skin): 23 people, 60.53%
  7. Carbon Dioxide Abnormal: 23 people, 60.53%
  8. Weight Increased: 23 people, 60.53%
  9. Glomerular Filtration Rate Decreased: 23 people, 60.53%
  10. Lipids Increased (excess lipid in body): 23 people, 60.53%

What are the existing conditions these people have? *

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 24 people, 63.16%

* Approximation only. Some reports may have incomplete information.

Do you take Arava and have Nail abnormalities?

- Check whether Nail abnormalities is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Arava:

Nail abnormalities treatments and more:

How severe was Nail abnormalities and when was it recovered:

Expand to all the drugs that have ingredients of leflunomide:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nail abnormalities:

Browse all the conditions that are associated with Nail abnormalities:

Drugs similar to Arava and Nail abnormalities :

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Arava) and Arava (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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