Arcalyst and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Arcalyst (rilonacept), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ilaris, and have Pericarditis.

The phase IV clinical study analyzes which people have Fatigue when taking Arcalyst. It is created by eHealthMe based on reports of 337 people who have side effects when taking Arcalyst from the FDA, and is updated regularly.

What is Arcalyst?

Arcalyst has active ingredients of rilonacept. eHealthMe is studying from 337 Arcalyst users. Check the latest studies of Arcalyst.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,032 drugs and 6,346 conditions by eHealthMe. Check the latest studies of Fatigue.

On Dec, 27, 2025

337 people reported to have side effects when taking Arcalyst.
Among them, 26 people (7.72%) have Fatigue.

Among these 26 people:

How long have people been on Arcalyst when they have Fatigue? *

What is the gender of people who have Fatigue when taking Arcalyst? *

female: 61.9 %
male: 38.1 %

What is the age of people who have Fatigue when taking Arcalyst? *

What are other drugs people take besides Arcalyst? *

What are other side effects people have besides Fatigue? *

Chest Pain: 7 people, 26.92%
Dyspnea (difficult or laboured breathing): 7 people, 26.92%
Muscle Aches (muscle pain): 6 people, 23.08%
Fever: 5 people, 19.23%
Rashes (redness): 5 people, 19.23%
Peripheral Swelling: 5 people, 19.23%
Muscle Spasms (muscle contraction): 4 people, 15.38%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 15.38%
Back Pain: 4 people, 15.38%
Ocular Discomfort (a generic expression when there is lack of ease in/about the eyes): 4 people, 15.38%

What are the existing conditions these people have? *

Pericarditis (inflammation of the pericardium): 9 people, 34.62%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 15.38%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 4 people, 15.38%
Hypersensitivity: 4 people, 15.38%
High Blood Pressure: 4 people, 15.38%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 15.38%
Anaemia (lack of blood): 4 people, 15.38%
Histiocytosis Haematophagic: 3 people, 11.54%
Staphylococcal Infection (an infection with staphylococcus bacteria): 2 people, 7.69%
Pericardial Effusion (fluid around the heart): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Arcalyst and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition (FREE)
- Predict drug outcomes for up to one year with AI (FREE)
- Get an AI agent to monitor your drugs continuously (FREE)

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Arcalyst:

Arcalyst (337 reports)

Fatigue treatments and more:

Fatigue (967,491 reports)

Browse all side effects of Arcalyst:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,032 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,346 conditions)

Related publications that referenced our studies

Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on rilonacept (the active ingredients of Arcalyst) and Arcalyst (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.