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Aredia and Hyperaesthesia - a phase IV clinical study of FDA data

Summary:

Hyperaesthesia is reported as a side effect among people who take Aredia (pamidronate disodium), especially for people who are female, 40-49 old, have been taking the drug for 5 - 10 years also take Zometa, and have Pain.

The phase IV clinical study analyzes which people have Hyperaesthesia when taking Aredia. It is created by eHealthMe based on reports of 15,280 people who have side effects when taking Aredia from the FDA, and is updated regularly.

What is Aredia?

Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,364 Aredia users. Check the latest studies of Aredia.

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 855 drugs and 916 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

On Jun, 23, 2026

15,280 people reported to have side effects when taking Aredia.
Among them, 78 people (0.51%) have Hyperaesthesia.

Could Aredia cause Hyperaesthesia?

Among these 78 people:

How long have people been on Aredia when they have Hyperaesthesia? *

  • < 1 month: 22.73 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 13.64 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 63.64 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyperaesthesia when taking Aredia? *

  • female: 84 %
  • male: 16 %

What is the age of people who have Hyperaesthesia when taking Aredia? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.43 %
  • 30-39: 0.0 %
  • 40-49: 47.14 %
  • 50-59: 38.57 %
  • 60+: 12.86 %

What are other drugs people take besides Aredia? *

  1. Zometa: 36 people, 46.15%
  2. Neurontin: 31 people, 39.74%
  3. Femara: 30 people, 38.46%
  4. Zofran: 28 people, 35.90%
  5. Clonidine: 28 people, 35.90%
  6. Zoloft: 28 people, 35.90%
  7. Lunesta: 26 people, 33.33%
  8. Ultram: 24 people, 30.77%
  9. Gabapentin: 21 people, 26.92%
  10. Xanax: 20 people, 25.64%

What are other side effects people have besides Hyperaesthesia? *

  1. Pain: 61 people, 78.21%
  2. Injury: 56 people, 71.79%
  3. Stress And Anxiety: 56 people, 71.79%
  4. Osteonecrosis Of Jaw (death of bone of jaw): 53 people, 67.95%
  5. Depression: 52 people, 66.67%
  6. Joint Pain: 46 people, 58.97%
  7. Neuropathy Peripheral (surface nerve damage): 43 people, 55.13%
  8. Diarrhea: 39 people, 50.00%
  9. Bone Disorder: 38 people, 48.72%
  10. Osteoporosis (bones weak and more likely to break): 36 people, 46.15%

What are the existing conditions these people have? *

  1. Pain: 26 people, 33.33%
  2. Depression: 17 people, 21.79%
  3. Bone Loss: 16 people, 20.51%
  4. Stress And Anxiety: 15 people, 19.23%
  5. Oedema (fluid collection in tissue): 15 people, 19.23%
  6. Hypomania (a mild form of mania, marked by elation and hyperactivity): 15 people, 19.23%
  7. Neoplasm Malignant (cancer tumour): 11 people, 14.10%
  8. High Blood Pressure: 8 people, 10.26%
  9. Breast Cancer Metastatic: 6 people, 7.69%
  10. Bone Disorder: 6 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Aredia and have Hyperaesthesia?

- Check whether Hyperaesthesia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aredia:

Hyperaesthesia treatments and more:

How severe was Hyperaesthesia and when was it recovered:

Expand to all the drugs that have ingredients of pamidronate disodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aredia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperaesthesia:

Browse all the conditions that are associated with Hyperaesthesia:

How the study uses the data?

The study uses data from the FDA. It is based on pamidronate disodium (the active ingredients of Aredia) and Aredia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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