Aredia and Roundback - a phase IV clinical study of FDA data

Summary:

Roundback is reported as a side effect among people who take Aredia (pamidronate disodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Roundback when taking Aredia. It is created by eHealthMe based on reports of 15,280 people who have side effects when taking Aredia from the FDA, and is updated regularly.

What is Aredia?

Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,364 Aredia users. Check the latest studies of Aredia.

What is Roundback?

Roundback (abnormal rearward curvature of the spine) is found to be associated with 1,230 drugs and 728 conditions by eHealthMe. Check the latest studies of Roundback.

On Sep, 06, 2025

15,280 people reported to have side effects when taking Aredia.
Among them, 518 people (3.39%) have Roundback.

Among these 518 people:

How long have people been on Aredia when they have Roundback? *

What is the gender of people who have Roundback when taking Aredia? *

female: 55.69 %
male: 44.31 %

What is the age of people who have Roundback when taking Aredia? *

What are other drugs people take besides Aredia? *

What are other side effects people have besides Roundback? *

Osteonecrosis Of Jaw (death of bone of jaw): 463 people, 89.38%
Pain: 451 people, 87.07%
Stress And Anxiety: 388 people, 74.90%
Back Pain: 356 people, 68.73%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 321 people, 61.97%
Bone Disorder: 314 people, 60.62%
Osteomyelitis (infection of bone): 300 people, 57.92%
Anaemia (lack of blood): 284 people, 54.83%
Osteopenia (a condition where bone mineral density is lower than normal): 280 people, 54.05%
Atelectasis (partial or complete collapse of the lung): 267 people, 51.54%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 131 people, 25.29%
Breast Cancer Metastatic: 55 people, 10.62%
Osteoporosis (bones weak and more likely to break): 49 people, 9.46%
Stress And Anxiety: 38 people, 7.34%
Pain: 37 people, 7.14%
Depression: 37 people, 7.14%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 29 people, 5.60%
Back Pain: 22 people, 4.25%
High Blood Pressure: 20 people, 3.86%
Muscle Spasms (muscle contraction): 18 people, 3.47%

* Approximation only. Some reports may have incomplete information.

Do you take Aredia and have Roundback?

- Check whether Roundback is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aredia:

Aredia (15,364 reports)

Roundback treatments and more:

Roundback (3,242 reports)

Common Aredia side effects:

Browse all side effects of Aredia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Roundback:

Browse all the drugs that are associated with Roundback:

Roundback (1,230 drugs)

Common conditions associated with Roundback:

Browse all the conditions that are associated with Roundback:

Roundback (728 conditions)

Drugs similar to Aredia and Roundback :

How the study uses the data?

The study uses data from the FDA. It is based on pamidronate disodium (the active ingredients of Aredia) and Aredia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.