Aricept and Bipolar disorder - a phase IV clinical study of FDA data

Summary:

Bipolar disorder is reported as a side effect among people who take Aricept (donepezil hydrochloride), especially for people who are female, 60+ old, also take Klonopin, and have Depression.

The phase IV clinical study analyzes which people have Bipolar disorder when taking Aricept. It is created by eHealthMe based on reports of 23,732 people who have side effects when taking Aricept from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Bipolar disorder?

Bipolar disorder (mood disorder) is found to be associated with 907 drugs and 1,231 conditions by eHealthMe. Check the latest studies of Bipolar disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

23,732 people reported to have side effects when taking Aricept.
Among them, 23 people (0.1%) have Bipolar disorder.

Among these 23 people:

What is the gender of people who have Bipolar disorder when taking Aricept? *

female: 69.57 %
male: 30.43 %

What is the age of people who have Bipolar disorder when taking Aricept? *

What are other drugs people take besides Aricept? *

What are other side effects people have besides Bipolar disorder? *

Stress And Anxiety: 7 people, 30.43%
Insomnia (sleeplessness): 7 people, 30.43%
Weight Decreased: 5 people, 21.74%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 21.74%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 17.39%
Drug Ineffective: 4 people, 17.39%
Weight Increased: 4 people, 17.39%
Nightmares (unpleasant dreams): 4 people, 17.39%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 17.39%
Back Pain: 4 people, 17.39%

What are the existing conditions these people have? *

Depression: 7 people, 30.43%
Pain: 5 people, 21.74%
Headache (pain in head): 4 people, 17.39%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 13.04%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 13.04%
Weight Decreased: 3 people, 13.04%
Quit Smoking: 3 people, 13.04%
Sleep Disorder: 2 people, 8.70%
High Blood Cholesterol: 2 people, 8.70%
Stress And Anxiety: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Aricept and have Bipolar disorder?

- Check whether Bipolar disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aricept:

Aricept (24,756 reports)

Bipolar disorder treatments and more:

Bipolar disorder (109,431 reports)

Browse all side effects of Aricept:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar disorder:

Bipolar disorder (907 drugs)

Browse all the conditions that are associated with Bipolar disorder:

Bipolar disorder (1,231 conditions)

Related publications that referenced our studies

Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Aricept) and Aricept (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.