Aripiprazole and Gastrointestinal perforation - a phase IV clinical study of FDA data

Summary:

Gastrointestinal perforation is reported as a side effect among people who take Aripiprazole (aripiprazole), especially for people who are female, 40-49 old, also take Pantoprazole, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Gastrointestinal perforation when taking Aripiprazole. It is created by eHealthMe based on reports of 38,853 people who have side effects when taking Aripiprazole from the FDA, and is updated regularly.

What is Aripiprazole?

Aripiprazole has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 39,143 Aripiprazole users. Check the latest studies of Aripiprazole.

What is Gastrointestinal perforation?

Gastrointestinal perforation (hole in the digestive tract) is found to be associated with 929 drugs and 1,394 conditions by eHealthMe. Check the latest studies of Gastrointestinal perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

38,853 people reported to have side effects when taking Aripiprazole.
Among them, 55 people (0.14%) have Gastrointestinal perforation.

Could Aripiprazole cause Gastrointestinal perforation?

Among these 55 people:

What is the gender of people who have Gastrointestinal perforation when taking Aripiprazole? *

female: 79.59 %
male: 20.41 %

What is the age of people who have Gastrointestinal perforation when taking Aripiprazole? *

What are other drugs people take besides Aripiprazole? *

Pantoprazole: 39 people, 70.91%
Sulfamethoxazole: 12 people, 21.82%
Mitoxantrone: 8 people, 14.55%
Olanzapine: 6 people, 10.91%
Levofloxacin: 6 people, 10.91%
Amoxicillin And Clavulanate Potassium: 5 people, 9.09%
Cefuroxime Axetil: 5 people, 9.09%
Cefuroxime: 5 people, 9.09%
Sulfamethoxazole And Trimethoprim: 4 people, 7.27%
Trimethoprim: 4 people, 7.27%

What are other side effects people have besides Gastrointestinal perforation? *

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 41 people, 74.55%
Pseudomembranous Colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon): 38 people, 69.09%
Trimethylaminuria (trimethylamine builds up in the body of patients with trimethylaminuria. the trimethylamine gets released in the person's sweat, urine, reproductive fluids, and breath, giving off a strong fishy or body odour): 37 people, 67.27%
Megacolon (a very dilated colon): 33 people, 60.00%
Drug Ineffective: 27 people, 49.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 26 people, 47.27%
Abdominal Pain Upper: 25 people, 45.45%
Diarrhea: 25 people, 45.45%
Bacterial Test Positive: 23 people, 41.82%
Fever: 23 people, 41.82%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 40 people, 72.73%
Urinary Tract Infection: 27 people, 49.09%
Bacterial Infection: 23 people, 41.82%
Diarrhea: 22 people, 40.00%
Bacterial Test Positive: 17 people, 30.91%
Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 15 people, 27.27%
Abdominal Pain: 15 people, 27.27%
Bacteriuria (presence of bacteria in urine): 13 people, 23.64%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 11 people, 20.00%
Psychotic Disorder: 11 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Aripiprazole and have Gastrointestinal perforation?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aripiprazole:

Aripiprazole (39,143 reports)

Browse all side effects of Aripiprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (929 drugs)

Browse all the conditions that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (1,394 conditions)

Related publications that referenced our studies

Cetin, M., Celik, M., Cakici, M., Polat, M., & Suner, A, "Aripiprazole-Induced Hoarseness", Turk Psikiyatri Dergisi, 2018 Jan .
Cetin M, Celik M, Cakici M, Polat M, Suner A, "Aripiprazole induced non-cardiogenic pulmonary edema: a case report", Turk Psikiyatri Dergisi, 2014 Dec .
Cetin, M., Celik, M., Cakici, M., Polat, M., & Suner, A, "Aripiprazole-Induced Hoarseness", Turk Psikiyatri Dergisi, 2018 Jan .
Cetin M, Celik M, Cakici M, Polat M, Suner A, "Aripiprazole induced non-cardiogenic pulmonary edema: a case report", Turk Psikiyatri Dergisi, 2014 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on aripiprazole (the active ingredients of Aripiprazole) and Aripiprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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