Artane and Enlarged heart - a phase IV clinical study of FDA data

Summary:

Enlarged heart is reported as a side effect among people who take Artane (trihexyphenidyl hydrochloride), especially for people who are male, 60+ old, also take Permax, and have Schizophrenia.

The phase IV clinical study analyzes which people have Enlarged heart when taking Artane. It is created by eHealthMe based on reports of 3,524 people who have side effects when taking Artane from the FDA, and is updated regularly.

What is Artane?

Artane has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,619 Artane users. Check the latest studies of Artane.

What is Enlarged heart?

Enlarged heart is found to be associated with 1,445 drugs and 1,667 conditions by eHealthMe. Check the latest studies of Enlarged heart.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

3,524 people reported to have side effects when taking Artane.
Among them, 13 people (0.37%) have Enlarged heart.

Among these 13 people:

What is the gender of people who have Enlarged heart when taking Artane? *

female: 30.77 %
male: 69.23 %

What is the age of people who have Enlarged heart when taking Artane? *

What are other drugs people take besides Artane? *

Permax: 6 people, 46.15%
Carbidopa And Levodopa: 5 people, 38.46%
Symmetrel: 4 people, 30.77%
Cabergoline: 4 people, 30.77%
Parlodel: 3 people, 23.08%
Estazolam: 2 people, 15.38%
Seroquel: 2 people, 15.38%
Pramipexole Dihydrochloride: 2 people, 15.38%
Zyprexa: 1 person, 7.69%
Amlodipine: 1 person, 7.69%

What are other side effects people have besides Enlarged heart? *

Tricuspid Valve Incompetence (inefficient heart valve): 6 people, 46.15%
Right Ventricular Failure (right half of the heart fails to work): 6 people, 46.15%
Mitral Valve Incompetence (inefficient heart valve): 6 people, 46.15%
Oedema Peripheral (superficial swelling): 5 people, 38.46%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 30.77%
Aortic Valve Incompetence: 4 people, 30.77%
Sick Sinus Syndrome (a collection of heart rhythm disorders): 4 people, 30.77%
Hypotension (abnormally low blood pressure): 4 people, 30.77%
Cardiac Arrest: 4 people, 30.77%
Pleural Effusion (water on the lungs): 4 people, 30.77%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 15.38%
Neuralgia (pain in one or more nerves): 1 person, 7.69%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 7.69%
High Blood Pressure: 1 person, 7.69%
Gastric Ulcer (stomach ulcer): 1 person, 7.69%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 1 person, 7.69%
Dyslipidaemia (abnormal amount of lipids): 1 person, 7.69%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 7.69%
Cancer Pain: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Artane and have Enlarged heart?

- Check whether Enlarged heart is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Artane:

Artane (3,619 reports)

Enlarged heart treatments and more:

Enlarged heart (20,022 reports)

Browse all side effects of Artane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Enlarged heart:

Enlarged heart (1,445 drugs)

Browse all the conditions that are associated with Enlarged heart:

Enlarged heart (1,667 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trihexyphenidyl hydrochloride (the active ingredients of Artane) and Artane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.