Ascorbate and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Ascorbate (vitamin c (ascorbic acid)), especially for people who are female, 60+ old, also take Acetaminophen, and have Rheumatoid arthritis.

The study is created by eHealthMe based on reports of 1,412 people who have side effects when taking Ascorbate from the FDA, and is updated regularly.

What is Ascorbate?

Ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 1,446 Ascorbate users. Check the latest studies of Ascorbate.

On Apr, 25, 2026

1,412 people reported to have side effects when taking Ascorbate.
Among them, 47 people (3.33%) died.

Among these 47 people:

What is the gender of people who died when taking Ascorbate? *

female: 57.5 %
male: 42.5 %

What is the age of people who died when taking Ascorbate? *

What are other drugs people take besides Ascorbate? *

Acetaminophen: 19 people, 40.43%
Vitamin C: 17 people, 36.17%
Prednisone: 13 people, 27.66%
Humira: 13 people, 27.66%
Folic Acid: 13 people, 27.66%
Potassium Chloride: 12 people, 25.53%
Erelzi: 11 people, 23.40%
Orencia: 11 people, 23.40%
Methotrexate: 11 people, 23.40%
Hydroxychloroquine Sulfate: 11 people, 23.40%

What are other side effects people have before they died? *

Nausea (feeling of having an urge to vomit): 10 people, 21.28%
Nausea And Vomiting: 9 people, 19.15%
General Physical Health Deterioration (weak health status): 8 people, 17.02%
Sepsis (a severe blood infection that can lead to organ failure and death): 7 people, 14.89%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 7 people, 14.89%
Ventricular Fibrillation (abnormally irregular heart rhythm): 7 people, 14.89%
Cardiogenic Shock (inadequate circulation of blood): 7 people, 14.89%
Blood Phosphorus Increased: 7 people, 14.89%
Ascites (accumulation of fluid in the abdominal cavity): 7 people, 14.89%
Appendicitis (inflammation of the appendix): 7 people, 14.89%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 27.66%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 21.28%
Migraine (headache): 10 people, 21.28%
High Blood Cholesterol: 9 people, 19.15%
Sleep Disorder: 9 people, 19.15%
Psoriasis (immune-mediated disease that affects the skin): 8 people, 17.02%
Anaemia (lack of blood): 7 people, 14.89%
Dyspnea (difficult or laboured breathing): 7 people, 14.89%
Diabetes: 7 people, 14.89%
Ventricular Fibrillation (abnormally irregular heart rhythm): 7 people, 14.89%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ascorbate:

Ascorbate (1,446 reports)

Expand to all the drugs that have ingredients of vitamin c (ascorbic acid):

Death and drugs with ingredients of vitamin c (ascorbic acid) (187 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ascorbate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,156 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on vitamin c (ascorbic acid) (the active ingredients of Ascorbate) and Ascorbate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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