Ascorbate and Hyponatraemia - a phase IV clinical study of FDA data

Summary:

Hyponatraemia is reported as a side effect among people who take Ascorbate (vitamin c (ascorbic acid)), especially for people who are male, 60+ old, also take Potassium Chloride, and have Constipation.

The phase IV clinical study analyzes which people have Hyponatraemia when taking Ascorbate. It is created by eHealthMe based on reports of 1,412 people who have side effects when taking Ascorbate from the FDA, and is updated regularly.

What is Ascorbate?

Ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 1,446 Ascorbate users. Check the latest studies of Ascorbate.

What is Hyponatraemia?

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 2,609 drugs and 2,429 conditions by eHealthMe. Check the latest studies of Hyponatraemia.

On Jun, 21, 2026

1,412 people reported to have side effects when taking Ascorbate.
Among them, 18 people (1.27%) have Hyponatraemia.

Among these 18 people:

What is the gender of people who have Hyponatraemia when taking Ascorbate? *

female: 20 %
male: 80 %

What is the age of people who have Hyponatraemia when taking Ascorbate? *

What are other drugs people take besides Ascorbate? *

Potassium Chloride: 16 people, 88.89%
Lansoprazole: 15 people, 83.33%
Lanthanum Carbonate: 15 people, 83.33%
Polyethylene Glycol 3350: 15 people, 83.33%
Phytonadione: 15 people, 83.33%
Ondansetron: 15 people, 83.33%
Metronidazole: 15 people, 83.33%
Melatonin: 15 people, 83.33%
Gabapentin: 15 people, 83.33%
Simvastatin: 15 people, 83.33%

What are other side effects people have besides Hyponatraemia? *

Abdominal Distension: 16 people, 88.89%
Abdominal Pain: 16 people, 88.89%
Nausea And Vomiting: 15 people, 83.33%
Appendicitis (inflammation of the appendix): 15 people, 83.33%
Stress And Anxiety: 15 people, 83.33%
Ascites (accumulation of fluid in the abdominal cavity): 15 people, 83.33%
Sepsis (a severe blood infection that can lead to organ failure and death): 15 people, 83.33%
Cardiogenic Shock (inadequate circulation of blood): 15 people, 83.33%
Constipation: 15 people, 83.33%
General Physical Health Deterioration (weak health status): 15 people, 83.33%

What are the existing conditions these people have? *

Anaemia (lack of blood): 15 people, 83.33%
Diabetes: 15 people, 83.33%
Dyspnea (difficult or laboured breathing): 15 people, 83.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 15 people, 83.33%
Ventricular Fibrillation (abnormally irregular heart rhythm): 15 people, 83.33%
Cardiogenic Shock (inadequate circulation of blood): 15 people, 83.33%
Iron Deficiency: 15 people, 83.33%
Blood Uric Acid Increased: 15 people, 83.33%
Nausea (feeling of having an urge to vomit): 15 people, 83.33%
Constipation: 15 people, 83.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ascorbate and have Hyponatraemia?

- Check whether Hyponatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ascorbate:

Ascorbate (1,446 reports)

Hyponatraemia treatments and more:

Hyponatraemia (72,436 reports)

Browse all side effects of Ascorbate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatraemia:

Hyponatraemia (2,610 drugs)

Browse all the conditions that are associated with Hyponatraemia:

Hyponatraemia (2,429 conditions)

Related publications that referenced our studies

Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .
Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on vitamin c (ascorbic acid) (the active ingredients of Ascorbate) and Ascorbate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.