Augmentin '125' and Hepatic necrosis - a phase IV clinical study of FDA data

Summary:

Hepatic necrosis is reported as a side effect among people who take Augmentin '125' (amoxicillin; clavulanate potassium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Nexium, and have Pneumonia.

The phase IV clinical study analyzes which people have Hepatic necrosis when taking Augmentin '125'. It is created by eHealthMe based on reports of 10,373 people who have side effects when taking Augmentin '125' from the FDA, and is updated regularly.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

What is Hepatic necrosis?

Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 595 drugs and 743 conditions by eHealthMe. Check the latest studies of Hepatic necrosis.

On Jul, 14, 2026

10,373 people reported to have side effects when taking Augmentin '125'.
Among them, 33 people (0.32%) have Hepatic necrosis.

Could Augmentin '125' cause Hepatic necrosis?

Among these 33 people:

How long have people been on Augmentin '125' when they have Hepatic necrosis? *

What is the gender of people who have Hepatic necrosis when taking Augmentin '125'? *

female: 40.62 %
male: 59.38 %

What is the age of people who have Hepatic necrosis when taking Augmentin '125'? *

What are other drugs people take besides Augmentin '125'? *

Nexium: 6 people, 18.18%
Tylenol: 3 people, 9.09%
Atarax: 3 people, 9.09%
Cordarone: 3 people, 9.09%
Ketek: 3 people, 9.09%
Citalopram Hydrobromide: 3 people, 9.09%
Esidrix: 2 people, 6.06%
Diflucan: 2 people, 6.06%
Glucophage: 2 people, 6.06%
Actigall: 2 people, 6.06%

What are other side effects people have besides Hepatic necrosis? *

Hepatic Failure (liver failure): 9 people, 27.27%
Nausea (feeling of having an urge to vomit): 7 people, 21.21%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 6 people, 18.18%
Hepatitis Cholestatic (flow of bile from the liver is slowed or blocked): 5 people, 15.15%
Blood Bilirubin Increased: 5 people, 15.15%
Liver Function Tests Nos Abnormal: 5 people, 15.15%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 5 people, 15.15%
Aspartate Aminotransferase Increased: 4 people, 12.12%
Hepatic Steatosis (fatty liver disease): 4 people, 12.12%
Fever: 4 people, 12.12%

What are the existing conditions these people have? *

Pneumonia: 2 people, 6.06%
Urinary Tract Infection: 1 person, 3.03%
Upper Respiratory Tract Infection: 1 person, 3.03%
Pain: 1 person, 3.03%
Haemoglobin Decreased: 1 person, 3.03%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 3.03%
Dyslipidaemia (abnormal amount of lipids): 1 person, 3.03%
Disseminated Tuberculosis: 1 person, 3.03%
Depression: 1 person, 3.03%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Augmentin '125' and have Hepatic necrosis?

- Check whether Hepatic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Augmentin '125':

Augmentin '125' (10,452 reports)

Hepatic necrosis treatments and more:

Hepatic necrosis (6,938 reports)

How severe was Hepatic necrosis and when was it recovered:

Hepatic necrosis in Augmentin '125'

Expand to all the drugs that have ingredients of amoxicillin; clavulanate potassium:

Hepatic necrosis and drugs with ingredients of amoxicillin; clavulanate potassium (88 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Augmentin '125':

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic necrosis:

Hepatic necrosis (595 drugs)

Browse all the conditions that are associated with Hepatic necrosis:

Hepatic necrosis (743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin; clavulanate potassium (the active ingredients of Augmentin '125') and Augmentin '125' (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.