Augmentin and Secondary sequestrum - a phase IV clinical study of FDA data

Summary:

Secondary sequestrum is reported as a side effect among people who take Augmentin (amoxicillin; clavulanate potassium), especially for people who are male, 60+ old, also take Zocor, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Secondary sequestrum when taking Augmentin. It is created by eHealthMe based on reports of 41,293 people who have side effects when taking Augmentin from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Secondary sequestrum?

Secondary sequestrum (a piece of dead bone that partially separates from sound bone during the process of necrosis but may be pushed back into position) is found to be associated with 50 drugs and 50 conditions by eHealthMe. Check the latest studies of Secondary sequestrum.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

41,293 people reported to have side effects when taking Augmentin.
Among them, 11 people (0.03%) have Secondary sequestrum.

Could Augmentin cause Secondary sequestrum?

Among these 11 people:

What is the gender of people who have Secondary sequestrum when taking Augmentin? *

female: 0.0 %
male: 100 %

What is the age of people who have Secondary sequestrum when taking Augmentin? *

What are other drugs people take besides Augmentin? *

What are other side effects people have besides Secondary sequestrum? *

Intervertebral Disc Degeneration (spinal disc degeneration): 11 people, 100.00%
Intervertebral Disc Space Narrowing (spinal disc space narrowing): 11 people, 100.00%
Oral Disorder (mouth disease): 11 people, 100.00%
Disease Progression: 11 people, 100.00%
Neck Pain: 11 people, 100.00%
Muscle Spasms (muscle contraction): 11 people, 100.00%
Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 11 people, 100.00%
Bruxism (habitual grinding of the teeth, typically during sleep): 11 people, 100.00%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 11 people, 100.00%
Joint Pain: 11 people, 100.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 100.00%
High Blood Pressure: 11 people, 100.00%
High Blood Cholesterol: 11 people, 100.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 100.00%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 27.27%
Pain: 3 people, 27.27%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Augmentin and have Secondary sequestrum?

- Check whether Secondary sequestrum is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Augmentin:

Augmentin (42,620 reports)

Secondary sequestrum treatments and more:

Secondary sequestrum (110 reports)

How severe was Secondary sequestrum and when was it recovered:

Secondary sequestrum in Augmentin

Expand to all the drugs that have ingredients of amoxicillin; clavulanate potassium:

Secondary sequestrum and drugs with ingredients of amoxicillin; clavulanate potassium (11 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Augmentin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Secondary sequestrum:

Secondary sequestrum (50 drugs)

Browse all the conditions that are associated with Secondary sequestrum:

Secondary sequestrum (50 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin; clavulanate potassium (the active ingredients of Augmentin) and Augmentin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.