Avandamet and Vitreous detachment - a phase IV clinical study of FDA data

Summary:

Vitreous detachment is reported as a side effect among people who take Avandamet (metformin hydrochloride; rosiglitazone maleate), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Aspirin, and have Arrhythmias.

The phase IV clinical study analyzes which people have Vitreous detachment when taking Avandamet. It is created by eHealthMe based on reports of 16,018 people who have side effects when taking Avandamet from the FDA, and is updated regularly.

What is Avandamet?

Avandamet has active ingredients of metformin hydrochloride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 16,084 Avandamet users. Check the latest studies of Avandamet.

What is Vitreous detachment?

Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina) is found to be associated with 411 drugs and 457 conditions by eHealthMe. Check the latest studies of Vitreous detachment.

On Aug, 02, 2026

16,018 people reported to have side effects when taking Avandamet.
Among them, 11 people (0.07%) have Vitreous detachment.

Could Avandamet cause Vitreous detachment?

Among these 11 people:

How long have people been on Avandamet when they have Vitreous detachment? *

What is the gender of people who have Vitreous detachment when taking Avandamet? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Vitreous detachment when taking Avandamet? *

What are other drugs people take besides Avandamet? *

What are other side effects people have besides Vitreous detachment? *

Headache (pain in head): 8 people, 72.73%
Cough: 8 people, 72.73%
Acute Kidney Failure: 8 people, 72.73%
Diarrhea: 8 people, 72.73%
Heart Rate Decreased: 7 people, 63.64%
Vitreous Haemorrhage (intraocular (inside the eye) bleeding): 7 people, 63.64%
Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease): 7 people, 63.64%
Fever: 7 people, 63.64%
Hyperkalemia (damage to or disease of the kidney): 7 people, 63.64%
Retinal Tear: 6 people, 54.55%

What are the existing conditions these people have? *

Arrhythmias (irregular heartbeat): 7 people, 63.64%
Ventricular Extrasystoles (premature cardiac contraction): 1 person, 9.09%
Metastases To Bone (cancer spreads to bone): 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Breast Cancer Recurrent: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Avandamet and have Vitreous detachment?

- Check whether Vitreous detachment is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Avandamet:

Avandamet (16,084 reports)

Vitreous detachment treatments and more:

Vitreous detachment (2,796 reports)

How severe was Vitreous detachment and when was it recovered:

Vitreous detachment in Avandamet

Expand to all the drugs that have ingredients of metformin hydrochloride; rosiglitazone maleate:

Vitreous detachment and drugs with ingredients of metformin hydrochloride; rosiglitazone maleate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Avandamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vitreous detachment:

Vitreous detachment (411 drugs)

Browse all the conditions that are associated with Vitreous detachment:

Vitreous detachment (457 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride; rosiglitazone maleate (the active ingredients of Avandamet) and Avandamet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.