Avastin and Macular hole - a phase IV clinical study of FDA data

Summary:

Macular hole is reported as a side effect among people who take Avastin (bevacizumab), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lucentis, and have Choroidal neovascularisation.

The phase IV clinical study analyzes which people have Macular hole when taking Avastin. It is created by eHealthMe based on reports of 75,729 people who have side effects when taking Avastin from the FDA, and is updated regularly.

What is Avastin?

Avastin has active ingredients of bevacizumab. It is often used in high blood cholesterol. eHealthMe is studying from 76,365 Avastin users. Check the latest studies of Avastin.

What is Macular hole?

Macular hole (small break in the macula, the central area of the retina) is found to be associated with 176 drugs and 529 conditions by eHealthMe. Check the latest studies of Macular hole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

75,729 people reported to have side effects when taking Avastin.
Among them, 45 people (0.06%) have Macular hole.

Among these 45 people:

How long have people been on Avastin when they have Macular hole? *

What is the gender of people who have Macular hole when taking Avastin? *

female: 45.24 %
male: 54.76 %

What is the age of people who have Macular hole when taking Avastin? *

What are other drugs people take besides Avastin? *

What are other side effects people have besides Macular hole? *

Visual Acuity Reduced (reduced clearness of vision): 7 people, 15.56%
Retinal Detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue): 7 people, 15.56%
Visual Impairment: 3 people, 6.67%
Choroidal Neovascularisation (creation of new blood vessels in vascular layer of eye): 3 people, 6.67%
Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank): 3 people, 6.67%
Vitreous Detachment (a condition of the eye in which the vitreous humour separates from the retina): 2 people, 4.44%
Blindness Unilateral: 2 people, 4.44%
Fatigue (feeling of tiredness): 2 people, 4.44%
Hearing Loss: 2 people, 4.44%
Herpes Zoster: 2 people, 4.44%

What are the existing conditions these people have? *

Choroidal Neovascularisation (creation of new blood vessels in vascular layer of eye): 9 people, 20.00%
Age-Related Macular Degeneration: 7 people, 15.56%
Nearsightedness (difficulty in seeing the far objects): 6 people, 13.33%
Retinal Neovascularisation (development of tiny, abnormal, leaky blood vessels inside the retina): 4 people, 8.89%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 4 people, 8.89%
Polypoidal Choroidal Vasculopathy (polyp-like sub-retinal pigment epithelium vascular abnormalities predominantly found in the macula and peripapillary region): 3 people, 6.67%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 3 people, 6.67%
Retinal Haemorrhage (bleeding from retina): 2 people, 4.44%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 1 person, 2.22%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Avastin and have Macular hole?

- Check whether Macular hole is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Avastin:

Avastin (76,365 reports)

Macular hole treatments and more:

Macular hole (1,673 reports)

Browse all side effects of Avastin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macular hole:

Macular hole (176 drugs)

Browse all the conditions that are associated with Macular hole:

Macular hole (529 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bevacizumab (the active ingredients of Avastin) and Avastin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.