Aviane-28 and Tinnitus - a phase IV clinical study of FDA data

Summary:

Tinnitus is reported as a side effect among people who take Aviane-28 (ethinyl estradiol; levonorgestrel), especially for people who are female, also take Differin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Tinnitus when taking Aviane-28. It is created by eHealthMe based on reports of 150 people who have side effects when taking Aviane-28 from the FDA, and is updated regularly.

What is Aviane-28?

Aviane-28 has active ingredients of ethinyl estradiol; levonorgestrel. It is often used in birth control. eHealthMe is studying from 286 Aviane-28 users. Check the latest studies of Aviane-28.

What is Tinnitus?

Tinnitus (a ringing in the ears) is found to be associated with 1,672 drugs and 3,053 conditions by eHealthMe. Check the latest studies of Tinnitus.

On Feb, 19, 2026

150 people reported to have side effects when taking Aviane-28.
Among them, 17 people (11.33%) have Tinnitus.

Among these 17 people:

What is the gender of people who have Tinnitus when taking Aviane-28? *

female: 100 %
male: 0.0 %

What are other drugs people take besides Aviane-28? *

Adapalene: 17 people, 100.00%
Calcitonin Salmon: 17 people, 100.00%
Flexeril: 17 people, 100.00%
Forteo: 17 people, 100.00%
Demerol: 17 people, 100.00%
Norco: 17 people, 100.00%
Prevacid: 17 people, 100.00%
Reglan: 17 people, 100.00%
Chlorhexidine Gluconate: 17 people, 100.00%
Differin: 17 people, 100.00%

What are other side effects people have besides Tinnitus? *

Weight Decreased: 17 people, 100.00%
Muscle Strain (an injury to a muscle in which the muscle fibres tear): 17 people, 100.00%
Migraine (headache): 17 people, 100.00%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 17 people, 100.00%
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 17 people, 100.00%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 17 people, 100.00%
Intervertebral Disc Protrusion (spinal disc protrusion): 17 people, 100.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 17 people, 100.00%
Injury: 17 people, 100.00%
Impaired Gastric Emptying: 17 people, 100.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 15 people, 88.24%
Sinus Disorder (disease of sinus): 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Aviane-28 and have Tinnitus?

- Check whether Tinnitus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aviane-28:

Aviane-28 (286 reports)

Tinnitus treatments and more:

Tinnitus (58,549 reports)

How severe was Tinnitus and when was it recovered:

Tinnitus in Aviane-28

Expand to all the drugs that have ingredients of ethinyl estradiol; levonorgestrel:

Tinnitus and drugs with ingredients of ethinyl estradiol; levonorgestrel (74 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aviane-28:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tinnitus:

Tinnitus (1,672 drugs)

Browse all the conditions that are associated with Tinnitus:

Tinnitus (3,053 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; levonorgestrel (the active ingredients of Aviane-28) and Aviane-28 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.