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Ayvakit and Executive dysfunction - a phase IV clinical study of FDA data

Summary:

Executive dysfunction is reported as a side effect among people who take Ayvakit (avapritinib), especially for people who are female, 60+ old, also take Hydroxyzine, and have Gastrointestinal stromal tumor.

The phase IV clinical study analyzes which people have Executive dysfunction when taking Ayvakit. It is created by eHealthMe based on reports of 7,362 people who have side effects when taking Ayvakit from the FDA, and is updated regularly.

What is Ayvakit?

Ayvakit has active ingredients of avapritinib. eHealthMe is studying from 7,362 Ayvakit users. Check the latest studies of Ayvakit.

What is Executive dysfunction?

Executive dysfunction is found to be associated with 50 drugs and 130 conditions by eHealthMe. Check the latest studies of Executive dysfunction.

On Apr, 03, 2026

7,362 people reported to have side effects when taking Ayvakit.
Among them, 6 people (0.08%) have Executive dysfunction.

Could Ayvakit cause Executive dysfunction?

Among these 6 people:

What is the gender of people who have Executive dysfunction when taking Ayvakit? *

  • female: 80 %
  • male: 20 %

What is the age of people who have Executive dysfunction when taking Ayvakit? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 20 %
  • 50-59: 0.0 %
  • 60+: 80 %

What are other drugs people take besides Ayvakit? *

  1. Zofran: 2 people, 33.33%
  2. Vitamin D3: 2 people, 33.33%
  3. Vitamin C: 2 people, 33.33%
  4. Vitamin B12: 2 people, 33.33%
  5. Sertraline: 2 people, 33.33%
  6. Rydapt: 2 people, 33.33%
  7. Qvar: 2 people, 33.33%
  8. Omeprazole: 2 people, 33.33%
  9. Metoprolol Tartrate: 2 people, 33.33%
  10. Hydroxyzine: 2 people, 33.33%

What are other side effects people have besides Executive dysfunction? *

  1. Confusional State: 5 people, 83.33%
  2. Diarrhea: 4 people, 66.67%
  3. Feeling Abnormal: 3 people, 50.00%
  4. Itching: 3 people, 50.00%
  5. Peripheral Swelling: 3 people, 50.00%
  6. Weakness: 2 people, 33.33%
  7. Nausea (feeling of having an urge to vomit): 2 people, 33.33%
  8. Abdominal Pain Upper: 2 people, 33.33%
  9. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 33.33%
  10. Blood Test Abnormal: 2 people, 33.33%

What are the existing conditions these people have? *

  1. Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 3 people, 50.00%
  2. Gastrointestinal Stromal Tumor: 3 people, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Ayvakit and have Executive dysfunction?

- Check whether Executive dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ayvakit:

Executive dysfunction treatments and more:

How severe was Executive dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of avapritinib:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ayvakit:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Executive dysfunction:

Browse all the conditions that are associated with Executive dysfunction:

How the study uses the data?

The study uses data from the FDA. It is based on avapritinib (the active ingredients of Ayvakit) and Ayvakit (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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