Ayvakit and Sciatica aggravated - a phase IV clinical study of FDA data

Summary:

Sciatica aggravated is reported as a side effect among people who take Ayvakit (avapritinib), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamins, and have Gastrointestinal stromal tumor.

The phase IV clinical study analyzes which people have Sciatica aggravated when taking Ayvakit. It is created by eHealthMe based on reports of 7,362 people who have side effects when taking Ayvakit from the FDA, and is updated regularly.

What is Ayvakit?

Ayvakit has active ingredients of avapritinib. eHealthMe is studying from 7,362 Ayvakit users. Check the latest studies of Ayvakit.

What is Sciatica aggravated?

Sciatica aggravated (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,043 drugs and 400 conditions by eHealthMe. Check the latest studies of Sciatica aggravated.

On Apr, 29, 2026

7,362 people reported to have side effects when taking Ayvakit.
Among them, 23 people (0.31%) have Sciatica aggravated.

Could Ayvakit cause Sciatica aggravated?

Among these 23 people:

How long have people been on Ayvakit when they have Sciatica aggravated? *

What is the gender of people who have Sciatica aggravated when taking Ayvakit? *

female: 52.17 %
male: 47.83 %

What is the age of people who have Sciatica aggravated when taking Ayvakit? *

What are other drugs people take besides Ayvakit? *

What are other side effects people have besides Sciatica aggravated? *

Memory Loss: 9 people, 39.13%
Fatigue (feeling of tiredness): 9 people, 39.13%
Insomnia (sleeplessness): 7 people, 30.43%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 6 people, 26.09%
Pain: 5 people, 21.74%
Dizziness: 5 people, 21.74%
Fall: 5 people, 21.74%
Headache (pain in head): 5 people, 21.74%
Diarrhea: 5 people, 21.74%
Nausea (feeling of having an urge to vomit): 4 people, 17.39%

What are the existing conditions these people have? *

Gastrointestinal Stromal Tumor: 13 people, 56.52%
Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 10 people, 43.48%
Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 13.04%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 8.70%
Sleep Disorder: 2 people, 8.70%
Nausea And Vomiting: 2 people, 8.70%
Nausea (feeling of having an urge to vomit): 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%
Haematopoietic Neoplasm (clonal disorders of blood cells cause abnormal mass of tissue cell): 2 people, 8.70%
Constipation: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Ayvakit and have Sciatica aggravated?

- Check whether Sciatica aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ayvakit:

Ayvakit (7,362 reports)

Browse all side effects of Ayvakit:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica aggravated:

Sciatica aggravated (1,043 drugs)

Browse all the conditions that are associated with Sciatica aggravated:

Sciatica aggravated (400 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on avapritinib (the active ingredients of Ayvakit) and Ayvakit (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.