Azelastine and Raynaud's phenomenon - a phase IV clinical study of FDA data

Summary:

Raynaud's phenomenon is reported as a side effect among people who take Azelastine (azelastine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Raynaud's phenomenon when taking Azelastine. It is created by eHealthMe based on reports of 17,147 people who have side effects when taking Azelastine from the FDA, and is updated regularly.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 628 drugs and 996 conditions by eHealthMe. Check the latest studies of Raynaud's phenomenon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

17,147 people reported to have side effects when taking Azelastine.
Among them, 19 people (0.11%) have Raynaud's phenomenon.

Could Azelastine cause Raynaud's phenomenon?

Among these 19 people:

How long have people been on Azelastine when they have Raynaud's phenomenon? *

What is the gender of people who have Raynaud's phenomenon when taking Azelastine? *

female: 94.74 %
male: 5.26 %

What is the age of people who have Raynaud's phenomenon when taking Azelastine? *

What are other drugs people take besides Azelastine? *

What are other side effects people have besides Raynaud's phenomenon? *

High Blood Pressure: 6 people, 31.58%
Osteoporosis (bones weak and more likely to break): 5 people, 26.32%
Swelling: 5 people, 26.32%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 21.05%
Dry Eyes (lack of adequate tears): 4 people, 21.05%
Neuropathy Peripheral (surface nerve damage): 4 people, 21.05%
Feeling Abnormal: 4 people, 21.05%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 21.05%
Fall: 4 people, 21.05%
Streptococcal Infection: 3 people, 15.79%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 57.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 42.11%
Drowsiness: 5 people, 26.32%
Multiple Allergies (allergy to multiple agents): 3 people, 15.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Oedema (fluid collection in tissue): 2 people, 10.53%
Depressed Level Of Consciousness: 2 people, 10.53%
Migraine (headache): 2 people, 10.53%
Serum Ferritin Decreased: 2 people, 10.53%
Chest Pain: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Azelastine and have Raynaud's phenomenon?

- Check whether Raynaud's phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Azelastine:

Azelastine (17,400 reports)

Browse all side effects of Azelastine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (628 drugs)

Browse all the conditions that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (996 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on azelastine hydrochloride (the active ingredients of Azelastine) and Azelastine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.